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Phase I trial of copanlisib, a selective PI3K inhibitor, in combination with cetuximab in patients with recurrent and/or metastatic head and neck squamous cell carcinoma.
Marret, Grégoire; Isambert, Nicolas; Rezai, Keyvan; Gal, Jocelyn; Saada-Bouzid, Esma; Rolland, Frédéric; Chausson, Maggy; Borcoman, Edith; Alt, Marie; Klijanienko, Jerzy; Vansteene, Damien; Guigay, Joël; Kamal, Maud; Bièche, Ivan; Le Tourneau, Christophe.
Affiliation
  • Marret G; Department of Drug Development and Innovation (D3i), Institut Curie, Paris & Saint-Cloud, France.
  • Isambert N; Department of Medical Oncology, Centre Georges-François Leclerc, Dijon, France.
  • Rezai K; Radio-Pharmacology Department, Institut Curie, Saint Cloud, France.
  • Gal J; Epidemiology and Biostatistics Unit, Centre Antoine Lacassagne, Nice, France.
  • Saada-Bouzid E; Department of Medical Oncology, Centre Antoine Lacassagne, Université Côte D'Azur, Nice, France.
  • Rolland F; Department of Medical Oncology, Institut René Gauducheau, Saint Herblain, France.
  • Chausson M; UNICANCER, Paris, France.
  • Borcoman E; Department of Drug Development and Innovation (D3i), Institut Curie, Paris & Saint-Cloud, France.
  • Alt M; Department of Drug Development and Innovation (D3i), Institut Curie, Paris & Saint-Cloud, France.
  • Klijanienko J; Department of Pathology, Institut Curie, Paris, France.
  • Vansteene D; Department of Medical Oncology, Institut René Gauducheau, Saint Herblain, France.
  • Guigay J; Department of Medical Oncology, Centre Antoine Lacassagne, Université Côte D'Azur, Nice, France.
  • Kamal M; Department of Drug Development and Innovation (D3i), Institut Curie, Paris & Saint-Cloud, France.
  • Bièche I; Department of Genetics, Institut Curie, Paris Descartes University, Paris, France.
  • Le Tourneau C; INSERM U1016, Cochin Institute, Paris, France.
Invest New Drugs ; 39(6): 1641-1648, 2021 12.
Article in En | MEDLINE | ID: mdl-34322775
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Full text: 1 Database: MEDLINE Main subject: Pyrimidines / Quinazolines / Squamous Cell Carcinoma of Head and Neck / Phosphoinositide-3 Kinase Inhibitors / Head and Neck Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Invest New Drugs Year: 2021 Type: Article Affiliation country: France
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Pyrimidines / Quinazolines / Squamous Cell Carcinoma of Head and Neck / Phosphoinositide-3 Kinase Inhibitors / Head and Neck Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Invest New Drugs Year: 2021 Type: Article Affiliation country: France