Inhibition of TNFAIP1 ameliorates the oxidative stress and inflammatory injury in myocardial ischemia/reperfusion injury through modulation of Akt/GSK-3ß/Nrf2 pathway.

Wen, Liang; Yang, Qing-Hui; Ma, Xiao-Lei; Li, Ting; Xiao, Sa; Sun, Chao-Feng

Wen, Liang; Yang, Qing-Hui; Ma, Xiao-Lei; Li, Ting; Xiao, Sa; Sun, Chao-Feng.

Affiliation

Wen L; Department of Cardiology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China; Department of Cardiology, Hanzhong Central Hospital, Hanzhong, Shaanxi 723000, China.
Yang QH; Department of Cardiology, Shanghai East Hospital, Tongji University, Shanghai 200120, China.
Ma XL; Department of Cardiology, Hanzhong Central Hospital, Hanzhong, Shaanxi 723000, China.
Li T; Department of Cardiology, Hanzhong Central Hospital, Hanzhong, Shaanxi 723000, China.
Xiao S; Department of Cardiology, Hanzhong Central Hospital, Hanzhong, Shaanxi 723000, China.
Sun CF; Department of Cardiology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China. Electronic address: sunchaofengcf@163.com.

Int Immunopharmacol ; 99: 107993, 2021 Oct.

Article in En | MEDLINE | ID: mdl-34330059

Subject(s)

Carrier Proteins/genetics; Inflammation/metabolism; Myocardial Reperfusion Injury/pathology; NF-E2-Related Factor 2/metabolism; Oxidative Stress/physiology; Proto-Oncogene Proteins c-akt/metabolism; Animals; Apoptosis/drug effects; Cells, Cultured; Cytokines/metabolism; Glycogen Synthase Kinase 3 beta/metabolism; Heterocyclic Compounds, 3-Ring/pharmacology; Hypoxia; Models, Animal; Myocytes, Cardiac; NF-E2-Related Factor 2/antagonists & inhibitors; Proto-Oncogene Proteins c-akt/antagonists & inhibitors; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species/metabolism; STAT1 Transcription Factor; Signal Transduction

Key words

Akt; Cardiomyocytes; Hypoxia/reoxygenation; Myocardial ischemia/reperfusion injury; Nrf2

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Full text: 1 Database: MEDLINE Main subject: Myocardial Reperfusion Injury / Carrier Proteins / Oxidative Stress / Proto-Oncogene Proteins c-akt / NF-E2-Related Factor 2 / Inflammation Type of study: Prognostic_studies Limits: Animals Language: En Journal: Int Immunopharmacol Journal subject: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Year: 2021 Type: Article Affiliation country: China

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