The modulation of transcriptional expression and inhibition of multidrug resistance associated protein 4 (MRP4) by analgesics and their primary metabolites.

Scialis, Renato J; Ghanem, Carolina I; Manautou, José E

Scialis, Renato J; Ghanem, Carolina I; Manautou, José E.

Affiliation

Scialis RJ; University of Connecticut, School of Pharmacy, Department of Pharmaceutical Sciences, Storrs, CT 06269, USA.
Ghanem CI; Instituto de Investigaciones Farmacológicas (ININFA), Facultad de Farmacia y Bioquímica, CONICET, Universidad de Buenos Aires, Buenos Aires, Argentina.
Manautou JE; Cátedra de Fisiopatología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina.

Curr Res Toxicol ; 1: 34-41, 2020 Jun 10.

Article in En | MEDLINE | ID: mdl-34345835

Key words

ALT, alanine aminotransferase; AMP, adenosine monophosphate; APAP, acetaminophen; APAP-CYS, acetaminophen cysteine; APAP-GLU, acetaminophen glucuronide; APAP-NAC, acetaminophen N-acetylcysteine; APAP-SUL, acetaminophen sulfate; ATP, adenosine triphosphate; Acetaminophen; DCF, diclofenac; DCF-AG, diclofenac acyl glucuronide; Diclofenac; Fmo, flavin containing monooxygenase; IS, internal standard; Inhibition; LTC4, leukotriene C4; MRP, multidrug resistance-associated protein; MRP4; Metabolite; OH-DCF, 4'-hydroxy diclofenac; PGE2, prostaglandin E2

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Full text: 1 Database: MEDLINE Type of study: Risk_factors_studies Language: En Journal: Curr Res Toxicol Year: 2020 Type: Article Affiliation country: United States

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Full text: 1 Database: MEDLINE Type of study: Risk_factors_studies Language: En Journal: Curr Res Toxicol Year: 2020 Type: Article Affiliation country: United States