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Dexamethasone may inhibit placental growth by blocking glucocorticoid receptors via phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin and reactive oxygen species/AMP-activated protein kinase signalling pathways in human placental JEG-3 cells.
Zhan, Xin; Xie, Yiran; Sun, Liping; Si, Qi; Shang, Hongkai.
Affiliation
  • Zhan X; Department of Obstetrics and Gynecology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
  • Xie Y; Reproductive Medicine Center, Taihe Hospital, Hubei Medical University, Shiyan 442000, China.
  • Sun L; Department of Obstetrics and Gynecology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
  • Si Q; Department of Obstetrics and Gynecology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
  • Shang H; Department of Obstetrics and Gynecology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; and Corresponding author. Email: hongkaishang@zju.edu.cn.
Reprod Fertil Dev ; 33(12): 700-712, 2021 Oct.
Article in En | MEDLINE | ID: mdl-34399087
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Full text: 1 Database: MEDLINE Main subject: Placenta / Dexamethasone / Signal Transduction / Receptors, Glucocorticoid / Reactive Oxygen Species Limits: Female / Humans / Pregnancy Language: En Journal: Reprod Fertil Dev Journal subject: MEDICINA REPRODUTIVA Year: 2021 Type: Article Affiliation country: China
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Full text: 1 Database: MEDLINE Main subject: Placenta / Dexamethasone / Signal Transduction / Receptors, Glucocorticoid / Reactive Oxygen Species Limits: Female / Humans / Pregnancy Language: En Journal: Reprod Fertil Dev Journal subject: MEDICINA REPRODUTIVA Year: 2021 Type: Article Affiliation country: China