A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease.
Nat Genet
; 53(9): 1276-1282, 2021 09.
Article
in En
| MEDLINE
| ID: mdl-34493870
ABSTRACT
Late-onset Alzheimer's disease is a prevalent age-related polygenic disease that accounts for 50-70% of dementia cases. Currently, only a fraction of the genetic variants underlying Alzheimer's disease have been identified. Here we show that increased sample sizes allowed identification of seven previously unidentified genetic loci contributing to Alzheimer's disease. This study highlights microglia, immune cells and protein catabolism as relevant to late-onset Alzheimer's disease, while identifying and prioritizing previously unidentified genes of potential interest. We anticipate that these results can be included in larger meta-analyses of Alzheimer's disease to identify further genetic variants that contribute to Alzheimer's pathology.
Full text:
1
Database:
MEDLINE
Main subject:
Genetic Predisposition to Disease
/
Genome-Wide Association Study
/
Alzheimer Disease
Type of study:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Nat Genet
Journal subject:
GENETICA MEDICA
Year:
2021
Type:
Article
Affiliation country:
Netherlands