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GWAS meta-analysis followed by Mendelian randomization revealed potential control mechanisms for circulating α-Klotho levels.
Gergei, Ingrid; Zheng, Jie; Andlauer, Till F M; Brandenburg, Vincent; Mirza-Schreiber, Nazanin; Müller-Myhsok, Bertram; Krämer, Bernhard K; Richard, Daniel; Falk, Louise; Movérare-Skrtic, Sofia; Ohlsson, Claes; Davey Smith, George; März, Winfried; Voelkl, Jakob; Tobias, Jonathan H.
Affiliation
  • Gergei I; Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), University Medical Center, Medical Faculty Mannheim, University of Heidelberg, Mannheim 69117, Germany.
  • Zheng J; Therapeutic Area Cardiovascular Medicine, Boehringer Ingelheim International GmbH, Ingelheim 06877, Germany.
  • Andlauer TFM; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.
  • Brandenburg V; Population Health Science, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK.
  • Mirza-Schreiber N; Max Planck Institute of Psychiatry, Munich 80804, Germany.
  • Müller-Myhsok B; Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich 80333, Germany.
  • Krämer BK; Department of Cardiology and Nephrology, Rhein-Maas Klinikum Würselen, Würselen 52146, Germany.
  • Richard D; Institute of Neurogenomics, Helmholtz Zentrum München, Neuherberg 85764, Germany.
  • Falk L; Max Planck Institute of Psychiatry, Munich 80804, Germany.
  • Movérare-Skrtic S; Munich Cluster for Systems Neurology (SyNergy), Munich 2145, Germany.
  • Ohlsson C; Institute of Translational Medicine, University of Liverpool, Liverpool 11341, UK.
  • Davey Smith G; Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), University Medical Center, Medical Faculty Mannheim, University of Heidelberg, Mannheim 69117, Germany.
  • März W; European Center for Angioscience ECAS, Medical Faculty Mannheim, University of Heidelberg, Mannheim 69117, Germany.
  • Voelkl J; Center for Preventive Medicine and Digital Health Baden-Württemberg (CPDBW), Medical Faculty Mannheim, Heidelberg University, Mannheim 69117, Germany.
  • Tobias JH; Department of Human Evolutionary Biology, Harvard University, Cambridge 02138, MA, USA.
Hum Mol Genet ; 31(5): 792-802, 2022 03 03.
Article in En | MEDLINE | ID: mdl-34542150
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Full text: 1 Database: MEDLINE Main subject: Genome-Wide Association Study / Mendelian Randomization Analysis Type of study: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2022 Type: Article Affiliation country: Germany
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Full text: 1 Database: MEDLINE Main subject: Genome-Wide Association Study / Mendelian Randomization Analysis Type of study: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2022 Type: Article Affiliation country: Germany