Maternal Cigarette Smoking and Cleft Lip and Palate: A Systematic Review and Meta-Analysis.
Cleft Palate Craniofac J
; 59(9): 1185-1200, 2022 09.
Article
in En
| MEDLINE
| ID: mdl-34569861
ABSTRACT
A systematic review and meta-analysis to determine the association between active maternal smoking and cleft lip and palate etiology.Medline, Embase, Web of Science and the Cochrane Library from inception to November, 2020.Observational studies of cigarette smoking habits in pregnant women. Outcomes included cleft lip and/or palate, cleft lip ± palate and cleft palate only.Publication bias analyses were performed and the Newcastle Ottawa scales were used to assess study quality. Fixed or random effect models were used in the meta-analysis, dependent on risk of statistical heterogeneity.Forty-five studies were eligible for inclusion of which 11 were cohort and 34 were case-control studies. Sixteen studies were of sufficient standard for inclusion in the meta-analysis. The summary odds ratio for the association between smoking and cleft lip and/or palate was 1.42 (95%CI 1.27-1.59) with a population attributable fraction of 4% (95%CI 3%-5%). There was limited evidence to show a dose-response effect of smoking.This review reports a moderate association between maternal smoking and orofacial cleft but the overall quality of the conventional observational studies included was poor. There is a need for high quality and novel research strategies to further define the role of smoking in the etiology of cleft lip and palate.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Prenatal Exposure Delayed Effects
/
Cleft Lip
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Cleft Palate
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Cigarette Smoking
Type of study:
Etiology_studies
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Observational_studies
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Risk_factors_studies
/
Systematic_reviews
Limits:
Female
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Humans
/
Pregnancy
Language:
En
Journal:
Cleft Palate Craniofac J
Journal subject:
ODONTOLOGIA
Year:
2022
Type:
Article
Affiliation country:
United kingdom