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CD4+ T cell immunity to Salmonella is transient in the circulation.
Peres, Newton G; Wang, Nancy; Whitney, Paul; Engel, Sven; Shreenivas, Meghanashree M; Comerford, Ian; Hocking, Dianna M; Erazo, Anna B; Förster, Irmgard; Kupz, Andreas; Gebhardt, Thomas; McColl, Shaun R; McSorley, Stephen J; Bedoui, Sammy; Strugnell, Richard A.
Affiliation
  • Peres NG; Department of Microbiology & Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
  • Wang N; European Molecular Biology Laboratory Australia Node for Single Molecule Science, School of Medical Sciences, The University of New South Wales, Kensington, Australia.
  • Whitney P; Department of Microbiology & Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
  • Engel S; Department of Microbiology & Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
  • Shreenivas MM; Department of Microbiology & Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
  • Comerford I; Department of Microbiology & Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
  • Hocking DM; School of Biological Science, Faculty of Sciences, The University of Adelaide, South Australia, Australia.
  • Erazo AB; Department of Microbiology & Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
  • Förster I; Department of Microbiology & Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
  • Kupz A; Immunology & Environment, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
  • Gebhardt T; Immunology & Environment, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
  • McColl SR; Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Australia.
  • McSorley SJ; Department of Microbiology & Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
  • Bedoui S; School of Biological Science, Faculty of Sciences, The University of Adelaide, South Australia, Australia.
  • Strugnell RA; Center for Comparative Medicine, University of California, Davis, California, United States of America.
PLoS Pathog ; 17(10): e1010004, 2021 10.
Article in En | MEDLINE | ID: mdl-34695149
ABSTRACT
While Salmonella enterica is seen as an archetypal facultative intracellular bacterial pathogen where protection is mediated by CD4+ T cells, identifying circulating protective cells has proved very difficult, inhibiting steps to identify key antigen specificities. Exploiting a mouse model of vaccination, we show that the spleens of C57BL/6 mice vaccinated with live-attenuated Salmonella serovar Typhimurium (S. Typhimurium) strains carried a pool of IFN-γ+ CD4+ T cells that could adoptively transfer protection, but only transiently. Circulating Salmonella-reactive CD4+ T cells expressed the liver-homing chemokine receptor CXCR6, accumulated over time in the liver and assumed phenotypic characteristics associated with tissue-associated T cells. Liver memory CD4+ T cells showed TCR selection bias and their accumulation in the liver could be inhibited by blocking CXCL16. These data showed that the circulation of CD4+ T cells mediating immunity to Salmonella is limited to a brief window after which Salmonella-specific CD4+ T cells migrate to peripheral tissues. Our observations highlight the importance of triggering tissue-specific immunity against systemic infections.
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Full text: 1 Database: MEDLINE Main subject: Salmonella Infections, Animal / CD4-Positive T-Lymphocytes / Immunologic Memory / Liver Type of study: Prognostic_studies Limits: Animals Language: En Journal: PLoS Pathog Year: 2021 Type: Article Affiliation country: Australia
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Full text: 1 Database: MEDLINE Main subject: Salmonella Infections, Animal / CD4-Positive T-Lymphocytes / Immunologic Memory / Liver Type of study: Prognostic_studies Limits: Animals Language: En Journal: PLoS Pathog Year: 2021 Type: Article Affiliation country: Australia