Association of Poor Sleep With Depressive and Anxiety Symptoms by HIV Disease Status: Women's Interagency HIV Study.
J Acquir Immune Defic Syndr
; 89(2): 222-230, 2022 02 01.
Article
in En
| MEDLINE
| ID: mdl-34732681
ABSTRACT
BACKGROUND:
Sleep disturbances are prevalent in women living with HIV (WLWH) and can affect mental health and overall quality of life. We examined the prevalence and predictors of poor sleep quality in a US cohort of WLWH and HIV-uninfected controls and the relationship between sleep quality and mental health symptom burden stratified by HIV disease status (viremic WLWH, aviremic WLWH, and HIV-uninfected women).METHODS:
Sleep quality was assessed using the Pittsburgh Sleep Quality Index in 1583 (400 viremic WLWH, 723 aviremic WLWH, and 460 HIV-uninfected women) Women's Interagency HIV Study participants. Depressive and anxiety symptoms were concurrently assessed using the Center for Epidemiological Studies-Depression (CES-D) scale and General Anxiety Disorder (GAD-7) scale. Associations between poor sleep quality (global Pittsburgh Sleep Quality Index >5) and both high depressive (CES-D ≥16) and anxiety (GAD-7 ≥10) symptoms were each assessed by HIV disease status using multivariable logistic regression models.RESULTS:
Prevalence of poor sleep quality in the overall sample was 52%, differed by HIV disease status (P = 0.045), and was significantly associated with high depressive and anxiety symptoms in (1) viremic WLWH, (2) aviremic WLWH, and (3) HIV-uninfected women [CES-D (1) adjusted odds ratio (aOR) = 7.50, 95% confidence interval (CI) 4.10 to 13.7; (2) aOR = 4.54, 95% CI 3.07 to 6.73; and (3) aOR = 6.03, 95% CI 3.50 to 10.4; GAD-7 (1) aOR = 5.20; 95% CI 2.60 to 10.4, (2) aOR = 6.03; 95% CI 3.67 to 9.91, and (3) aOR = 6.24; 95% CI 3.11 to 12.6].CONCLUSIONS:
Poor sleep quality is highly prevalent, as is mental health symptom burden, among WLWH and HIV-uninfected controls. Future longitudinal studies are necessary to clarify the directionality of the relationship.
Full text:
1
Database:
MEDLINE
Main subject:
Quality of Life
/
HIV Infections
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
Language:
En
Journal:
J Acquir Immune Defic Syndr
Journal subject:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Year:
2022
Type:
Article
Affiliation country:
Israel