Synthesis, molecular modeling and cholinesterase inhibitory effects of 2-indolinone-based hydrazinecarbothioamides.

Demir-Yazici, Kübra; Apaydin, Çagla Begüm; Soylu-Eter, Özge; Özsoy, Nurten; Karali, Nilgün

Demir-Yazici, Kübra; Apaydin, Çagla Begüm; Soylu-Eter, Özge; Özsoy, Nurten; Karali, Nilgün.

Affiliation

Demir-Yazici K; Department of Pharmaceutical Chemistry, Istanbul University, Istanbul, 34116, Turkey.
Apaydin ÇB; Department of Pharmaceutical Chemistry, Istanbul University, Istanbul, 34116, Turkey.
Soylu-Eter Ö; Department of Pharmaceutical Chemistry, Istanbul University, Istanbul, 34116, Turkey.
Özsoy N; Department of Biochemistry, Istanbul University, Istanbul, 34116, Turkey.
Karali N; Department of Pharmaceutical Chemistry, Istanbul University, Istanbul, 34116, Turkey.

Future Med Chem ; 13(24): 2133-2151, 2021 12.

Article in En | MEDLINE | ID: mdl-34755546

Subject(s)

Acetylcholinesterase/metabolism; Alzheimer Disease/drug therapy; Butyrylcholinesterase/metabolism; Cholinesterase Inhibitors/pharmacology; Hydrazines/pharmacology; Oxindoles/pharmacology; Thioamides/pharmacology; Alzheimer Disease/metabolism; Cholinesterase Inhibitors/chemical synthesis; Cholinesterase Inhibitors/chemistry; Humans; Hydrazines/chemical synthesis; Hydrazines/chemistry; Models, Molecular; Molecular Structure; Oxindoles/chemistry; Thioamides/chemical synthesis; Thioamides/chemistry

Key words

2-indolinone; acetylcholinesterase; butyrylcholinesterase; hydrazinecarbothioamide; molecular modeling; sulfonamide

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Full text: 1 Database: MEDLINE Main subject: Acetylcholinesterase / Thioamides / Butyrylcholinesterase / Cholinesterase Inhibitors / Alzheimer Disease / Oxindoles / Hydrazines Limits: Humans Language: En Journal: Future Med Chem Year: 2021 Type: Article Affiliation country: Turkey

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