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Rhea, the reaction knowledgebase in 2022.
Bansal, Parit; Morgat, Anne; Axelsen, Kristian B; Muthukrishnan, Venkatesh; Coudert, Elisabeth; Aimo, Lucila; Hyka-Nouspikel, Nevila; Gasteiger, Elisabeth; Kerhornou, Arnaud; Neto, Teresa Batista; Pozzato, Monica; Blatter, Marie-Claude; Ignatchenko, Alex; Redaschi, Nicole; Bridge, Alan.
Affiliation
  • Bansal P; Swiss-Prot group, SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, CH-1211 Geneva 4, Switzerland.
  • Morgat A; Swiss-Prot group, SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, CH-1211 Geneva 4, Switzerland.
  • Axelsen KB; Swiss-Prot group, SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, CH-1211 Geneva 4, Switzerland.
  • Muthukrishnan V; Swiss-Prot group, SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, CH-1211 Geneva 4, Switzerland.
  • Coudert E; Swiss-Prot group, SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, CH-1211 Geneva 4, Switzerland.
  • Aimo L; Swiss-Prot group, SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, CH-1211 Geneva 4, Switzerland.
  • Hyka-Nouspikel N; Swiss-Prot group, SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, CH-1211 Geneva 4, Switzerland.
  • Gasteiger E; Swiss-Prot group, SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, CH-1211 Geneva 4, Switzerland.
  • Kerhornou A; Swiss-Prot group, SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, CH-1211 Geneva 4, Switzerland.
  • Neto TB; Swiss-Prot group, SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, CH-1211 Geneva 4, Switzerland.
  • Pozzato M; Swiss-Prot group, SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, CH-1211 Geneva 4, Switzerland.
  • Blatter MC; Swiss-Prot group, SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, CH-1211 Geneva 4, Switzerland.
  • Ignatchenko A; EMBL-EBI European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Redaschi N; Swiss-Prot group, SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, CH-1211 Geneva 4, Switzerland.
  • Bridge A; Swiss-Prot group, SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, CH-1211 Geneva 4, Switzerland.
Nucleic Acids Res ; 50(D1): D693-D700, 2022 01 07.
Article in En | MEDLINE | ID: mdl-34755880
Rhea (https://www.rhea-db.org) is an expert-curated knowledgebase of biochemical reactions based on the chemical ontology ChEBI (Chemical Entities of Biological Interest) (https://www.ebi.ac.uk/chebi). In this paper, we describe a number of key developments in Rhea since our last report in the database issue of Nucleic Acids Research in 2019. These include improved reaction coverage in Rhea, the adoption of Rhea as the reference vocabulary for enzyme annotation in the UniProt knowledgebase UniProtKB (https://www.uniprot.org), the development of a new Rhea website, and the designation of Rhea as an ELIXIR Core Data Resource. We hope that these and other developments will enhance the utility of Rhea as a reference resource to study and engineer enzymes and the metabolic systems in which they function.
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Full text: 1 Database: MEDLINE Main subject: Software / Databases, Factual / Chemical Phenomena Limits: Animals / Humans Language: En Journal: Nucleic Acids Res Year: 2022 Type: Article Affiliation country: Switzerland
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Full text: 1 Database: MEDLINE Main subject: Software / Databases, Factual / Chemical Phenomena Limits: Animals / Humans Language: En Journal: Nucleic Acids Res Year: 2022 Type: Article Affiliation country: Switzerland