Cordycepin Ameliorates Intracerebral Hemorrhage Induced Neurological and Cognitive Impairments Through Reducing Anti-Oxidative Stress in a Mouse Model.

ABSTRACT

OBJECTIVES: The nerve damage and cognitive impairment caused by intracerebral hemorrhage (ICH) seriously affect the quality of life of patients. Cordycepin has been reported to have antioxidant and neuroprotective functions. However, the therapeutic effect of cordycepin on cognitive impairment caused by ICH is still unclear. MATERIALS AND METHODS: Autologous whole blood was injected into the basal ganglia to construct a mouse ICH model. The Modified Neurological Severity Score was used to assess nerve damage in mice. The wet/dry method was used to detect brain water content. Open field test was used to assess the anxiety of mice. Morris water maze testing, Y-maze test and nest-building test were used to evaluate the cognitive function of mice. qRT-PCR and western blotting assay were used to evaluate the expression of genes. RESULTS: Cordycepin treatment could ameliorate ICH-induced neurological deficits, brain edema, anxiety, cognitive impairments, oxidative stress and antioxidant capacity in ICH mice. CONCLUSION: Cordycepin ameliorates ICH-induced neurological and cognitive impairments through reducing anti-oxidative stress in mouse model.