Genomic Instability and Cancer Risk Associated with Erroneous DNA Repair.

Yoshioka, Ken-Ichi; Kusumoto-Matsuo, Rika; Matsuno, Yusuke; Ishiai, Masamichi

Yoshioka, Ken-Ichi; Kusumoto-Matsuo, Rika; Matsuno, Yusuke; Ishiai, Masamichi.

Affiliation

Yoshioka KI; Laboratory of Genome Stability Maintenance, National Cancer Center Research Institute, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
Kusumoto-Matsuo R; Laboratory of Genome Stability Maintenance, National Cancer Center Research Institute, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
Matsuno Y; Laboratory of Genome Stability Maintenance, National Cancer Center Research Institute, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
Ishiai M; Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.

Int J Mol Sci ; 22(22)2021 Nov 12.

Article in En | MEDLINE | ID: mdl-34830134

Subject(s)

DNA Breaks, Double-Stranded; DNA End-Joining Repair/genetics; Genomic Instability; Neoplasms/genetics; Animals; BRCA1 Protein/genetics; BRCA1 Protein/metabolism; Humans; Neoplasms/metabolism; Rad51 Recombinase/genetics; Rad51 Recombinase/metabolism; Risk Factors; Tumor Suppressor p53-Binding Protein 1/genetics; Tumor Suppressor p53-Binding Protein 1/metabolism

Key words

chromosomal instability (CIN); genomic instability; homologous recombination (HR); microhomology-mediated end-joining (MMEJ); microsatellite instability (MSI); mismatch repair (MMR); non-homologous end-joining (NHEJ); nucleotide excision repair (NER)

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Full text: 1 Database: MEDLINE Main subject: Genomic Instability / DNA Breaks, Double-Stranded / DNA End-Joining Repair / Neoplasms Type of study: Etiology_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Int J Mol Sci Year: 2021 Type: Article Affiliation country: Japan

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