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Briarane-Related Diterpenoids from Octocoral Briareum stechei.
Huynh, Thanh-Hao; Neoh, Choo-Aun; Tsai, Yu-Chi; Yao, Zhi-Kang; Zheng, Li-Guo; Huang, Pin-Chang; Wen, Zhi-Hong; Chen, Jih-Jung; Wu, Yu-Jen; Sung, Ping-Jyun.
Affiliation
  • Huynh TH; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan.
  • Neoh CA; National Museum of Marine Biology and Aquarium, Pingtung 944401, Taiwan.
  • Tsai YC; Department of Research, Pingtung Christian Hospital, Pingtung 900026, Taiwan.
  • Yao ZK; National Museum of Marine Biology and Aquarium, Pingtung 944401, Taiwan.
  • Zheng LG; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan.
  • Huang PC; Department of Orthopedics, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan.
  • Wen ZH; National Museum of Marine Biology and Aquarium, Pingtung 944401, Taiwan.
  • Chen JJ; National Museum of Marine Biology and Aquarium, Pingtung 944401, Taiwan.
  • Wu YJ; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan.
  • Sung PJ; Institute of BioPharmaceutical Sciences, National Sun Yat-sen University, Kaohsiung 804201, Taiwan.
Molecules ; 26(22)2021 Nov 13.
Article in En | MEDLINE | ID: mdl-34833953
ABSTRACT
A known polyoxygenated briarane, briaexcavatolide P (1), was isolated from a Formosan octocoral Briareum stechei. Moreover, the same species B. stechei, collected from Okinawan waters, yielded three chlorine-containing briaranes, including two new compounds, briastecholides B (2) and C (3) as well as a known analogue, briarenol R (4). The structures of 1-4 were established using spectroscopic methods. In addition, briarane 1 demonstrated anti-inflammatory activity in lipo-polysaccharide-induced RAW 264.7 mouse macrophage cells by suppressing the expression of inducible nitric oxide synthase (iNOS) protein.
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Full text: 1 Database: MEDLINE Main subject: Anthozoa / Diterpenes Limits: Animals Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2021 Type: Article Affiliation country: Taiwan
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Full text: 1 Database: MEDLINE Main subject: Anthozoa / Diterpenes Limits: Animals Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2021 Type: Article Affiliation country: Taiwan