The therapeutic effect of hesperetin on doxorubicin-induced testicular toxicity: Potential roles of the mechanistic target of rapamycin kinase (mTOR) and dynamin-related protein 1 (DRP1).

Tektemur, Ahmet; Tektemur, Nalan Kaya; Güzel, Elif Erdem

Tektemur, Ahmet; Tektemur, Nalan Kaya; Güzel, Elif Erdem.

Affiliation

Tektemur A; Department of Medical Biology, Faculty of Medicine, Firat University, Elazig, Turkey. Electronic address: atektemur@firat.edu.tr.
Tektemur NK; Department of Histology and Embryology, Faculty of Medicine, Firat University, Elazig, Turkey.
Güzel EE; Mardin Artuklu University, Faculty of Health Sciences, Department of Midwifery, Mardin, Turkey.

Toxicol Appl Pharmacol ; 435: 115833, 2022 01 15.

Article in En | MEDLINE | ID: mdl-34933056

Subject(s)

Antibiotics, Antineoplastic; Doxorubicin; Dynamins/biosynthesis; Hesperidin/therapeutic use; TOR Serine-Threonine Kinases/biosynthesis; Testicular Diseases/chemically induced; Testicular Diseases/drug therapy; Animals; Antioxidants/metabolism; Autophagy-Related Protein 5/biosynthesis; Autophagy-Related Protein 5/genetics; Beclin-1/biosynthesis; Beclin-1/genetics; Dynamins/genetics; Gene Expression/drug effects; Male; MicroRNAs/biosynthesis; Oxidative Stress; Rats; Rats, Sprague-Dawley; TOR Serine-Threonine Kinases/genetics; Testicular Diseases/pathology; Testis/drug effects; Testis/metabolism; Testis/pathology

Key words

DRP1; Doxorubicin; Hesperetin; Testis; mTOR

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Full text: 1 Database: MEDLINE Main subject: Testicular Diseases / Doxorubicin / Dynamins / TOR Serine-Threonine Kinases / Hesperidin / Antibiotics, Antineoplastic Limits: Animals Language: En Journal: Toxicol Appl Pharmacol Year: 2022 Type: Article

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