Apolipoprotein E Polymorphism, Cardiac Remodeling, and Heart Failure in the ARIC Study.
J Card Fail
; 28(7): 1128-1136, 2022 07.
Article
in En
| MEDLINE
| ID: mdl-34965472
ABSTRACT
BACKGROUND:
ß-Amyloid has recently been discovered in the myocardium of patients with Alzheimer's disease (AD). Whether genetic variation in apolipoprotein E (APOE) É4, a common variant associated with Alzheimer's disease, is associated with incident heart failure (HF), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and cardiac structure and function is unknown. METHODS ANDRESULTS:
We studied 15,064 White and Black participants in the Atherosclerosis Risk in Communities, relating genotype status at visit 1 (1987-1989) to incident HF hospitalization using Cox regression. At visits 2, 4, and 5, we assessed NT-proBNP levels by genotype. At visits 3 and 5, we related Aß peptides to incident HF. At visit 5 (2011-2013, nâ¯=â¯6251), we assessed the relationship of genotype with prevalent HF and echocardiographic parameters. The mean participant age was 54.7 ± 5.8 years, 45% were men, and 73% were White. At visit 5, there was no difference in prevalent HF by genotype. The APOE ε4 carriers did not have increased risk for HF hospitalization. The APOE ε4 genotype was not associated with cardiac structure and function or NT-proBNP levels. The Aß peptides were not associated with incident HF after multivariable adjustment.CONCLUSIONS:
A genetic predisposition to Alzheimer's disease through APOE ε4 is not associated with an increased prevalence of HF, HF hospitalization, myocardial remodeling, or biochemical evidence of HF.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Apolipoprotein E4
/
Alzheimer Disease
/
Heart Failure
Type of study:
Diagnostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Card Fail
Journal subject:
CARDIOLOGIA
Year:
2022
Type:
Article