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Effects of Long-Acting Somatostatin Analogues on Lipid Metabolism in Patients with Newly Diagnosed Acromegaly: A Retrospective Study of 120 Cases.
Shao, Xiao-Qing; Chen, Zheng-Yuan; Wang, Meng; Yang, Ye-Ping; Yu, Yi-Fei; Liu, Wen-Juan; Wang, Yi; Zeng, Fang-Fang; Gong, Wei; Ye, Hong-Ying; Wang, Yong-Fei; Zhao, Yao; Zhang, Li; Zhang, Zhao-Yun; He, Min; Li, Yi-Ming.
Affiliation
  • Shao XQ; Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China.
  • Chen ZY; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
  • Wang M; Shanghai Pituitary Tumor Center, Shanghai, China.
  • Yang YP; Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China.
  • Yu YF; Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China.
  • Liu WJ; Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China.
  • Wang Y; Shanghai Pituitary Tumor Center, Shanghai, China.
  • Zeng FF; Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China.
  • Gong W; Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China.
  • Ye HY; Shanghai Pituitary Tumor Center, Shanghai, China.
  • Wang YF; Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China.
  • Zhao Y; Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China.
  • Zhang L; Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China.
  • Zhang ZY; Shanghai Pituitary Tumor Center, Shanghai, China.
  • He M; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
  • Li YM; Shanghai Pituitary Tumor Center, Shanghai, China.
Horm Metab Res ; 54(1): 25-32, 2022 Jan.
Article in En | MEDLINE | ID: mdl-34986497
ABSTRACT
The short-term effects of long-acting somatostatin analogues (SSAs) on lipid profiles in patients with acromegaly are not well studied. We retrospectively analyzed the effects of SSAs on lipid profiles and associated cardiovascular risk factors in a cohort of 120 newly diagnosed acromegaly patients. In this study, 69 females and 51 males were included. These patients were treated with either octreotide LAR (OCT) or lanreotide SR (LAN) for 3 months. After SSAs treatment, both GH and IGF-1 significantly decreased (p<0.001). Triglyceride (TG), total to high-density lipoprotein cholesterol (HDL-C) ratio, and lipoprotein (a) [Lp(a)] levels were significantly decreased, while HDL-C levels were increased (p<0.05). The reduction of mean serum GH (GHm) was positively associated with the decrease of TG (r=0.305, p=0.001) and Lp(a) (r=0.257, p=0.005), as well as the increase of HDL-C (r=-0.355, p<0.001). The changes of lipid profiles were observed only in OCT group, but not in LAN group. In addition, systolic blood pressure (SBP) had significantly declined after SSAs treatment, with an average reduction of 4.4 mmHg (126.7±1.28 vs. 122.3±1.44 mmHg, p=0.003), while no change was observed regarding diastolic blood pressure (DBP) (p>0.05). Fasting insulin, fasting C-peptide, and HOMA-IR were significantly decreased after SSAs treatment. In conclusion, our current study revealed that short-term SSAs treatment improves lipid profiles and other cardiovascular risk factors in patients with acromegaly.
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Full text: 1 Database: MEDLINE Main subject: Acromegaly / Somatostatin / Lipid Metabolism Type of study: Diagnostic_studies / Observational_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male Language: En Journal: Horm Metab Res Year: 2022 Type: Article Affiliation country: China
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Full text: 1 Database: MEDLINE Main subject: Acromegaly / Somatostatin / Lipid Metabolism Type of study: Diagnostic_studies / Observational_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male Language: En Journal: Horm Metab Res Year: 2022 Type: Article Affiliation country: China