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Menthol in Combination with Iontophoresis Promotes Natamycin Penetration through the Cornea: In Vitro and In Vivo Studies.
Bai, J H; Ding, X M; Mou, H Y; Wang, S L; Chen, S H.
Affiliation
  • Bai JH; Department of Ophthalmology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang Province, China.
  • Ding XM; Department of Ophthalmology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang Province, China.
  • Mou HY; Department of Ophthalmology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang Province, China.
  • Wang SL; Department of Ophthalmology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang Province, China.
  • Chen SH; Center for Refractive Surgery, The Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China. baijh9422@tzzxyy.com.
Bull Exp Biol Med ; 172(3): 318-323, 2022 Jan.
Article in En | MEDLINE | ID: mdl-35001301
We studied whether menthol can promote penetration of natamycin, a representative antifungal macrolide agent, through the cornea. Natamycin penetration was examined using an in vitro iontophoresis system that simulates clinical scenario; menthol (0.1-0.3%, w/v) was added to the donor reservoir of a standard Franz diffusion chambers. In vivo effects of menthol on natamycin penetration were examined in a set of bioassays using rabbits inoculated with Aspergillus fumigatus in the right eye. Potential irritation to the rabbit eye was examined using a standard test. Menthol significantly (p<0.05) potentiated the effects of iontophoresis on natamycin penetration. The optimal combination seemed to be 0.2% menthol in combination with 3 mA/cm2 iontophoresis.
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Full text: 1 Database: MEDLINE Main subject: Natamycin / Keratitis Limits: Animals Language: En Journal: Bull Exp Biol Med Year: 2022 Type: Article Affiliation country: China

Full text: 1 Database: MEDLINE Main subject: Natamycin / Keratitis Limits: Animals Language: En Journal: Bull Exp Biol Med Year: 2022 Type: Article Affiliation country: China