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The role of fibroblast growth factor 8 in cartilage development and disease.
Chen, Haoran; Cui, Yujia; Zhang, Demao; Xie, Jing; Zhou, Xuedong.
Affiliation
  • Chen H; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
  • Cui Y; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
  • Zhang D; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
  • Xie J; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
  • Zhou X; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
J Cell Mol Med ; 26(4): 990-999, 2022 02.
Article in En | MEDLINE | ID: mdl-35001536
Fibroblast growth factor 8 (FGF-8), also known as androgen-induced growth factor (AIGF), is presumed to be a potent mitogenic cytokine that plays important roles in early embryonic development, brain formation and limb development. In the bone environment, FGF-8 produced or received by chondrocyte precursor cells binds to fibroblast growth factor receptor (FGFR), causing different levels of activation of downstream signalling pathways, such as phospholipase C gamma (PLCγ)/Ca2+ , RAS/mitogen-activated protein kinase-extracellular regulated protein kinases (RAS/MAPK-MEK-ERK), and Wnt-ß-catenin-Axin2 signalling, and ultimately controlling chondrocyte proliferation, differentiation, cell survival and migration. However, the molecular mechanism of FGF-8 in normal or pathological cartilage remains unclear, and thus, FGF-8 represents a novel exploratory target for studies of chondrocyte development and cartilage disease progression. In this review, studies assessing the relationship between FGF-8 and chondrocytes that have been published in the past 5 years are systematically summarized to determine the probable mechanism and physiological effect of FGF-8 on chondrocytes. Based on the existing research results, a therapeutic regimen targeting FGF-8 is proposed to explore the possibility of treating chondrocyte-related diseases.
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Full text: 1 Database: MEDLINE Main subject: Chondrogenesis / Fibroblast Growth Factors Language: En Journal: J Cell Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2022 Type: Article Affiliation country: China

Full text: 1 Database: MEDLINE Main subject: Chondrogenesis / Fibroblast Growth Factors Language: En Journal: J Cell Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2022 Type: Article Affiliation country: China