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Altering the binding determinant on the interdigitating loop of mandelate racemase shifts specificity towards that of d-tartrate dehydratase.
Nagar, Mitesh; Hayden, Joshua A; Sagey, Einat; Worthen, George; Park, Mika; Sharma, Amar Nath; Fetter, Christopher M; Kuehm, Oliver P; Bearne, Stephen L.
Affiliation
  • Nagar M; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
  • Hayden JA; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
  • Sagey E; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
  • Worthen G; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
  • Park M; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
  • Sharma AN; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
  • Fetter CM; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
  • Kuehm OP; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
  • Bearne SL; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, B3H 4R2, Canada; Department of Chemistry, Dalhousie University, Halifax, NS, B3H 4R2, Canada. Electronic address: sbearne@dal.ca.
Arch Biochem Biophys ; 718: 109119, 2022 03 30.
Article in En | MEDLINE | ID: mdl-35016855
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Full text: 1 Database: MEDLINE Main subject: Tartrates / Racemases and Epimerases Language: En Journal: Arch Biochem Biophys Year: 2022 Type: Article Affiliation country: Canada
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Full text: 1 Database: MEDLINE Main subject: Tartrates / Racemases and Epimerases Language: En Journal: Arch Biochem Biophys Year: 2022 Type: Article Affiliation country: Canada