A case for a national registry of red blood cell antibodies.
Vox Sang
; 117(5): 738-740, 2022 May.
Article
in En
| MEDLINE
| ID: mdl-35023153
ABSTRACT
BACKGROUND AND OBJECTIVES:
Red blood cell (RBC) antibody levels diminish over time and negative antibody screen are commonly seen in patients with a history of antibodies. Most hospitals do not have access to a shared registry of antibodies previously detected at other hospitals. MATERIALS ANDMETHODS:
We describe a case where the patient was found to be at high risk of bleeding during liver transplantation. Antibody screen on admission was negative but a history of anti-Jka was identified on reviewing patient's history in local registry of RBC antibodies. The surgery was pushed back to arrange for antigen-negative units. The patient received a total of 16 Jk(a-) RBC units during the admission.RESULTS:
No acute or delayed transfusion adverse reactions were seen. However, if the history of anti-Jka identified at another local hospital was not known, approximately three-quarters of the units transfused would have been Jk(a+). Transfusing Jk(a+) units could have potentially exposed the patient to risk of developing an acute and/or delayed haemolytic transfusion reaction which could have led to significant morbidity and perhaps mortality.CONCLUSION:
With this case report, we build a case for developing a national registry of RBC antibodies to help improve patient safety and outcomes.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Liver Transplantation
/
Isoantibodies
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Vox Sang
Year:
2022
Type:
Article
Affiliation country:
United States