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Reproductive Factors Do Not Influence Survival with Ovarian Cancer.
Phung, Minh Tung; Alimujiang, Aliya; Berchuck, Andrew; Anton-Culver, Hoda; Schildkraut, Joellen M; Bandera, Elisa V; Chang-Claude, Jenny; Chase, Anne; Doherty, Jennifer Anne; Grout, Bronwyn; Goodman, Marc T; Hanley, Gillian E; Lee, Alice W; McKinnon Deurloo, Cindy; Menon, Usha; Modugno, Francesmary; Pharoah, Paul D P; Pike, Malcolm C; Richardson, Jean; Risch, Harvey A; Sieh, Weiva; Terry, Kathryn L; Webb, Penelope M; Wentzensen, Nicolas; Wu, Anna H; Pearce, Celeste Leigh.
Affiliation
  • Phung MT; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan.
  • Alimujiang A; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan.
  • Berchuck A; Division of Gynecologic Oncology, Duke University School of Medicine, Durham, North Carolina.
  • Anton-Culver H; Department of Medicine, University of California Irvine, Irvine, California.
  • Schildkraut JM; Emory University Rollins School of Public Health, Atlanta, Georgia.
  • Bandera EV; Cancer Epidemiology and Health Outcomes, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey.
  • Chang-Claude J; Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
  • Chase A; Cancer Epidemiology Group, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Doherty JA; Patient Advocate.
  • Grout B; Department of Population Health Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah.
  • Goodman MT; Patient Advocate.
  • Hanley GE; Samuel Oschin Comprehensive Cancer Institute, Cancer Prevention and Genetics Program, Cedars-Sinai Medical Center, Los Angeles, California.
  • Lee AW; Department of Biomedical Sciences, Community and Population Health Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.
  • McKinnon Deurloo C; Department of Obstetrics and Gynecology, University of British Columbia Faculty of Medicine, Vancouver, Canada.
  • Menon U; Department of Public Health, California State University, Fullerton, Fullerton, California.
  • Modugno F; Patient Advocate.
  • Pharoah PDP; MRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, UCL, London, United Kingdom.
  • Pike MC; Women's Cancer Research Center, Magee-Women's Research Institute and Hillman Cancer Center, Pittsburgh, Pennsylvania.
  • Richardson J; Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
  • Risch HA; Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburg, Pennsylvania.
  • Sieh W; Department of Oncology, Center for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
  • Terry KL; Department of Public Health and Primary Care, Center for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
  • Webb PM; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
  • Wentzensen N; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Wu AH; Patient Advocate.
  • Pearce CL; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Cancer Epidemiol Biomarkers Prev ; 31(4): 909-913, 2022 04 01.
Article in En | MEDLINE | ID: mdl-35064059
ABSTRACT

BACKGROUND:

Previous studies on the association between reproductive factors and ovarian cancer survival are equivocal, possibly due to small sample sizes.

METHODS:

Using data on 11,175 people diagnosed with primary invasive epithelial ovarian, fallopian tube, or primary peritoneal cancer (ovarian cancer) from 16 studies in the Ovarian Cancer Association Consortium (OCAC), we examined the associations between survival and age at menarche, combined oral contraceptive use, parity, breastfeeding, age at last pregnancy, and menopausal status using Cox proportional hazard models. The models were adjusted for age at diagnosis, race/ethnicity, education level, and OCAC study and stratified on stage and histotype.

RESULTS:

During the mean follow-up of 6.34 years (SD = 4.80), 6,418 patients passed away (57.4%). There was no evidence of associations between the reproductive factors and survival among patients with ovarian cancer overall or by histotype.

CONCLUSIONS:

This study found no association between reproductive factors and survival after an ovarian cancer diagnosis. IMPACT Reproductive factors are well-established risk factors for ovarian cancer, but they are not associated with survival after a diagnosis of ovarian cancer.
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Full text: 1 Database: MEDLINE Main subject: Ovarian Neoplasms Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Pregnancy Language: En Journal: Cancer Epidemiol Biomarkers Prev Journal subject: BIOQUIMICA / EPIDEMIOLOGIA / NEOPLASIAS Year: 2022 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Ovarian Neoplasms Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Pregnancy Language: En Journal: Cancer Epidemiol Biomarkers Prev Journal subject: BIOQUIMICA / EPIDEMIOLOGIA / NEOPLASIAS Year: 2022 Type: Article