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Generation and characterization of human induced pluripotent stem cells (iPSCs) from three individuals without age-related macular degeneration.
Koolen, Louet; Gagliardi, Giuliana; Ten Brink, Sofie C A; de Breuk, Anita; Heesterbeek, Thomas J; Hoyng, Carel B; Albert, Silvia; den Hollander, Anneke I.
Affiliation
  • Koolen L; Department of Ophthalmology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: louet.koolen@radboudumc.nl.
  • Gagliardi G; Department of Ophthalmology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Ten Brink SCA; Department of Ophthalmology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands.
  • de Breuk A; Department of Ophthalmology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Heesterbeek TJ; Department of Ophthalmology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Hoyng CB; Department of Ophthalmology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Albert S; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.
  • den Hollander AI; Department of Ophthalmology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.
Stem Cell Res ; 60: 102670, 2022 04.
Article in En | MEDLINE | ID: mdl-35078129
Age-related macular degeneration (AMD) is a major cause of vision loss among the elderly in the Western world. AMD is multifactorial eye disease with a strong genetic contribution. Here, we report the generation and characterization of induced pluripotent stem cells (iPSCs) derived from peripheral blood mononuclear cells of three individuals above 70 years of age without AMD. These cell lines were generated to serve as control lines for cellular studies investigating the disease mechanisms and developing therapeutic interventions for AMD.
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Full text: 1 Database: MEDLINE Main subject: Induced Pluripotent Stem Cells / Macular Degeneration Limits: Aged / Humans Language: En Journal: Stem Cell Res Year: 2022 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Induced Pluripotent Stem Cells / Macular Degeneration Limits: Aged / Humans Language: En Journal: Stem Cell Res Year: 2022 Type: Article