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The tyrosine kinase inhibitor LPM4870108 impairs learning and memory and induces transcriptomic and gene­specific DNA methylation changes in rats.
Duan, Sijin; Li, Chunmei; Gao, Yonglin; Meng, Ping; Ji, Shengmin; Xu, Yangyang; Mao, Yutong; Wang, Hongbo; Tian, Jingwei.
Affiliation
  • Duan S; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, People's Republic of China.
  • Li C; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, People's Republic of China.
  • Gao Y; State Key Laboratory of Long-Acting Targeting Drug Delivery Technologies (Luye Pharma Group Ltd.), Yantai, 264003, People's Republic of China.
  • Meng P; School of Life Science, Yantai University, Yantai, 264005, People's Republic of China.
  • Ji S; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, People's Republic of China.
  • Xu Y; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, People's Republic of China.
  • Mao Y; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, People's Republic of China.
  • Wang H; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, People's Republic of China.
  • Tian J; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, People's Republic of China.
Arch Toxicol ; 96(3): 845-857, 2022 03.
Article in En | MEDLINE | ID: mdl-35098321
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Full text: 1 Database: MEDLINE Main subject: Maze Learning / DNA Methylation / Protein Kinase Inhibitors / Memory Disorders Limits: Animals Language: En Journal: Arch Toxicol Year: 2022 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Maze Learning / DNA Methylation / Protein Kinase Inhibitors / Memory Disorders Limits: Animals Language: En Journal: Arch Toxicol Year: 2022 Type: Article