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Genetically proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers: A mendelian randomization analysis.
Yarmolinsky, James; Díez-Obrero, Virginia; Richardson, Tom G; Pigeyre, Marie; Sjaarda, Jennifer; Paré, Guillaume; Walker, Venexia M; Vincent, Emma E; Tan, Vanessa Y; Obón-Santacana, Mireia; Albanes, Demetrius; Hampe, Jochen; Gsur, Andrea; Hampel, Heather; Pai, Rish K; Jenkins, Mark; Gallinger, Steven; Casey, Graham; Zheng, Wei; Amos, Christopher I; Smith, George Davey; Martin, Richard M; Moreno, Victor.
Affiliation
  • Yarmolinsky J; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.
  • Díez-Obrero V; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
  • Richardson TG; Biomarkers and Susceptibility Unit, Oncology Data Analytics Program, Catalan Institute of Oncology (ICO), L'Hospitalet de Llobregat, Barcelona, Spain.
  • Pigeyre M; Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
  • Sjaarda J; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
  • Paré G; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.
  • Walker VM; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
  • Vincent EE; Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Canada.
  • Tan VY; Thrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Canada.
  • Obón-Santacana M; Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Canada.
  • Albanes D; Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Canada.
  • Hampe J; Thrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Canada.
  • Gsur A; Department of Pathology and Molecular Medicine, McMaster University, Michael G. DeGroote School of Medicine, Hamilton, Canada.
  • Hampel H; Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Canada.
  • Pai RK; Thrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Canada.
  • Jenkins M; Department of Pathology and Molecular Medicine, McMaster University, Michael G. DeGroote School of Medicine, Hamilton, Canada.
  • Gallinger S; Department of Clinical Epidemiology and Biostatistics, McMaster University, Ontario, Canada.
  • Casey G; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.
  • Zheng W; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
  • Amos CI; Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
  • Smith GD; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.
  • Martin RM; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
  • Moreno V; Biomarkers and Susceptibility Unit, Oncology Data Analytics Program, Catalan Institute of Oncology (ICO), L'Hospitalet de Llobregat, Barcelona, Spain.
PLoS Med ; 19(2): e1003897, 2022 02.
Article in En | MEDLINE | ID: mdl-35113855
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Full text: 1 Database: MEDLINE Main subject: Receptors, Adrenergic, beta-1 / Peptidyl-Dipeptidase A / Mendelian Randomization Analysis / Neoplasms / Antihypertensive Agents Type of study: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male Language: En Journal: PLoS Med Journal subject: MEDICINA Year: 2022 Type: Article Affiliation country: United kingdom
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Full text: 1 Database: MEDLINE Main subject: Receptors, Adrenergic, beta-1 / Peptidyl-Dipeptidase A / Mendelian Randomization Analysis / Neoplasms / Antihypertensive Agents Type of study: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male Language: En Journal: PLoS Med Journal subject: MEDICINA Year: 2022 Type: Article Affiliation country: United kingdom