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Disposition of Nirmatrelvir, an Orally Bioavailable Inhibitor of SARS-CoV-2 3C-Like Protease, across Animals and Humans.
Eng, Heather; Dantonio, Alyssa L; Kadar, Eugene P; Obach, R Scott; Di, Li; Lin, Jian; Patel, Nandini C; Boras, Britton; Walker, Gregory S; Novak, Jonathan J; Kimoto, Emi; Singh, Ravi Shankar P; Kalgutkar, Amit S.
Affiliation
  • Eng H; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut (H.E., A.L.D., E.P.K., R.S.O., L.D., J.L., G.S.W., J.J.N., E.K.); Pfizer Worldwide Research and Development, Cambridge, Massachusetts (N.C.P., R.S.P.S., A.S.K.); and Pfizer Worldwide Research and Development, La Jolla, Californ
  • Dantonio AL; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut (H.E., A.L.D., E.P.K., R.S.O., L.D., J.L., G.S.W., J.J.N., E.K.); Pfizer Worldwide Research and Development, Cambridge, Massachusetts (N.C.P., R.S.P.S., A.S.K.); and Pfizer Worldwide Research and Development, La Jolla, Californ
  • Kadar EP; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut (H.E., A.L.D., E.P.K., R.S.O., L.D., J.L., G.S.W., J.J.N., E.K.); Pfizer Worldwide Research and Development, Cambridge, Massachusetts (N.C.P., R.S.P.S., A.S.K.); and Pfizer Worldwide Research and Development, La Jolla, Californ
  • Obach RS; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut (H.E., A.L.D., E.P.K., R.S.O., L.D., J.L., G.S.W., J.J.N., E.K.); Pfizer Worldwide Research and Development, Cambridge, Massachusetts (N.C.P., R.S.P.S., A.S.K.); and Pfizer Worldwide Research and Development, La Jolla, Californ
  • Di L; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut (H.E., A.L.D., E.P.K., R.S.O., L.D., J.L., G.S.W., J.J.N., E.K.); Pfizer Worldwide Research and Development, Cambridge, Massachusetts (N.C.P., R.S.P.S., A.S.K.); and Pfizer Worldwide Research and Development, La Jolla, Californ
  • Lin J; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut (H.E., A.L.D., E.P.K., R.S.O., L.D., J.L., G.S.W., J.J.N., E.K.); Pfizer Worldwide Research and Development, Cambridge, Massachusetts (N.C.P., R.S.P.S., A.S.K.); and Pfizer Worldwide Research and Development, La Jolla, Californ
  • Patel NC; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut (H.E., A.L.D., E.P.K., R.S.O., L.D., J.L., G.S.W., J.J.N., E.K.); Pfizer Worldwide Research and Development, Cambridge, Massachusetts (N.C.P., R.S.P.S., A.S.K.); and Pfizer Worldwide Research and Development, La Jolla, Californ
  • Boras B; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut (H.E., A.L.D., E.P.K., R.S.O., L.D., J.L., G.S.W., J.J.N., E.K.); Pfizer Worldwide Research and Development, Cambridge, Massachusetts (N.C.P., R.S.P.S., A.S.K.); and Pfizer Worldwide Research and Development, La Jolla, Californ
  • Walker GS; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut (H.E., A.L.D., E.P.K., R.S.O., L.D., J.L., G.S.W., J.J.N., E.K.); Pfizer Worldwide Research and Development, Cambridge, Massachusetts (N.C.P., R.S.P.S., A.S.K.); and Pfizer Worldwide Research and Development, La Jolla, Californ
  • Novak JJ; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut (H.E., A.L.D., E.P.K., R.S.O., L.D., J.L., G.S.W., J.J.N., E.K.); Pfizer Worldwide Research and Development, Cambridge, Massachusetts (N.C.P., R.S.P.S., A.S.K.); and Pfizer Worldwide Research and Development, La Jolla, Californ
  • Kimoto E; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut (H.E., A.L.D., E.P.K., R.S.O., L.D., J.L., G.S.W., J.J.N., E.K.); Pfizer Worldwide Research and Development, Cambridge, Massachusetts (N.C.P., R.S.P.S., A.S.K.); and Pfizer Worldwide Research and Development, La Jolla, Californ
  • Singh RSP; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut (H.E., A.L.D., E.P.K., R.S.O., L.D., J.L., G.S.W., J.J.N., E.K.); Pfizer Worldwide Research and Development, Cambridge, Massachusetts (N.C.P., R.S.P.S., A.S.K.); and Pfizer Worldwide Research and Development, La Jolla, Californ
  • Kalgutkar AS; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut (H.E., A.L.D., E.P.K., R.S.O., L.D., J.L., G.S.W., J.J.N., E.K.); Pfizer Worldwide Research and Development, Cambridge, Massachusetts (N.C.P., R.S.P.S., A.S.K.); and Pfizer Worldwide Research and Development, La Jolla, Californ
Drug Metab Dispos ; 50(5): 576-590, 2022 05.
Article in En | MEDLINE | ID: mdl-35153195
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Full text: 1 Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Drug Treatment Limits: Animals / Child / Humans Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2022 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Drug Treatment Limits: Animals / Child / Humans Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2022 Type: Article