Oncologic impact of concomitant prostate cancer characteristics at the time of radical cystoprostatectomy for bladder cancer: a population-based analysis.
Aging Male
; 25(1): 54-61, 2022 Dec.
Article
in En
| MEDLINE
| ID: mdl-35179092
ABSTRACT
OBJECTIVE:
The aim of this study was to evaluate the prognostic impact of concomitant prostate cancer (PCa) of the cancer-specific mortality (CSM) in the aging patient's papulation with bladder cancer (BCa) treated with radical cystoprostatectomy (RCP). MATERIALS ANDMETHODS:
Within the SEER database (2004-2015), 1468 patients were treated with RCP for BCa harboring histopathological PCa findings. To account for other cause mortality (OCM), multivariable competing risk regression (CRR) tested for potential BCa-CSM differences according to PCa characteristics risk factors predicting CSM.RESULTS:
CRR analysis revealed that only following BCa characteristics, as high pathological tumor stages(Ta/Tis/T1 [REF.] vs. T2; HR 2.03, 95% CI 1.16-3.57, p = 0.014 vs. T3; HR 4.32, 95% CI 2.45-7.61, p < 0.001 vs. T4; HR 5.06, 95% CI 2.77-9.22, p < 0.001), as well unfavorable BCa grade IV (Grade I-II [REF.] vs. Grade IV; HR 0.58, 95% CI 0.35-0.98, p < 0.041) achieved independent predictor status of CSM. With regard to PCa characteristics, none of the covariates yielded independent predictor status of CSM.CONCLUSIONS:
Our study, based on the largest population cohort, demonstrates that even in organ-confined BCa patients, concomitant PCa as second malignancy does not represent a risk factor for survival.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Prostatic Neoplasms
/
Urinary Bladder Neoplasms
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
/
Male
Language:
En
Journal:
Aging Male
Journal subject:
GERIATRIA
Year:
2022
Type:
Article
Affiliation country:
Germany