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Genome-wide association study reveals novel genetic loci: a new polygenic risk score for mitral valve prolapse.
Roselli, Carolina; Yu, Mengyao; Nauffal, Victor; Georges, Adrien; Yang, Qiong; Love, Katie; Weng, Lu-Chen; Delling, Francesca N; Maurya, Svetlana R; Schrölkamp, Maren; Tfelt-Hansen, Jacob; Hagège, Albert; Jeunemaitre, Xavier; Debette, Stéphanie; Amouyel, Philippe; Guan, Wyliena; Muehlschlegel, Jochen D; Body, Simon C; Shah, Svati; Samad, Zainab; Kyryachenko, Sergiy; Haynes, Carol; Rienstra, Michiel; Le Tourneau, Thierry; Probst, Vincent; Roussel, Ronan; Wijdh-Den Hamer, Inez J; Siland, Joylene E; Knowlton, Kirk U; Jacques Schott, Jean; Levine, Robert A; Benjamin, Emelia J; Vasan, Ramachandran S; Horne, Benjamin D; Muhlestein, Joseph B; Benfari, Giovanni; Enriquez-Sarano, Maurice; Natale, Andrea; Mohanty, Sanghamitra; Trivedi, Chintan; Shoemaker, Moore B; Yoneda, Zachary T; Wells, Quinn S; Baker, Michael T; Farber-Eger, Eric; Michelena, Hector I; Lundby, Alicia; Norris, Russell A; Slaugenhaupt, Susan A; Dina, Christian.
Affiliation
  • Roselli C; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Yu M; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Nauffal V; Université de Paris, PARCC, Inserm, F-75015 Paris, France.
  • Georges A; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Yang Q; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • Love K; Université de Paris, PARCC, Inserm, F-75015 Paris, France.
  • Weng LC; School of Public Health, Boston University, Boston, MA, USA.
  • Delling FN; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
  • Maurya SR; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Schrölkamp M; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
  • Tfelt-Hansen J; Division of Cardiology, University of California San Francisco, San Francisco, CA, USA.
  • Hagège A; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, København 2200, Denmark.
  • Jeunemaitre X; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, København 2200, Denmark.
  • Debette S; Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  • Amouyel P; Department of Forensic Medicine, Faculty of Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Guan W; Université de Paris, PARCC, Inserm, F-75015 Paris, France.
  • Muehlschlegel JD; Assistance Publique-Hôpitaux de Paris, Departments of Cardiology and Genetics, Hôpital Européen Georges Pompidou, 75015 Paris, France.
  • Body SC; Université de Paris, PARCC, Inserm, F-75015 Paris, France.
  • Shah S; Assistance Publique-Hôpitaux de Paris, Departments of Cardiology and Genetics, Hôpital Européen Georges Pompidou, 75015 Paris, France.
  • Samad Z; Bordeaux Population Health Research Center, Inserm Center U1219, University of Bordeaux, Bordeaux, France.
  • Kyryachenko S; Department of Neurology, Bordeaux University Hospital, Inserm U1219, Bordeaux, France.
  • Haynes C; Univ. Lille, Inserm, Centre Hosp. Univ Lille, Institut Pasteur de Lille, UMR1167 - RID-AGE- Risk factors and molecular determinants of aging-related diseases, F-59000 Lille, France.
  • Rienstra M; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Le Tourneau T; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
  • Probst V; Demoulas Center for Cardiac Arrhythmias, Massachusetts General Hospital, Boston, MA, USA.
  • Roussel R; Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • Wijdh-Den Hamer IJ; Department of Anesthesiology, Boston University School of Medicine, Boston, MA, USA.
  • Siland JE; Duke Molecular Physiology Institute, Duke University, Durham, NC, USA.
  • Knowlton KU; Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
  • Jacques Schott J; Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
  • Levine RA; Department of Medicine, Aga Khan University, Karachi, Pakistan.
  • Benjamin EJ; Université de Paris, PARCC, Inserm, F-75015 Paris, France.
  • Vasan RS; Duke Molecular Physiology Institute, Duke University, Durham, NC, USA.
  • Horne BD; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Muhlestein JB; l'institut du thorax, INSERM, CNRS, Univ Nantes, CHU Nantes, Nantes, France.
  • Benfari G; l'institut du thorax, CHU Nantes, Nantes, France.
  • Enriquez-Sarano M; l'institut du thorax, INSERM, CNRS, Univ Nantes, CHU Nantes, Nantes, France.
  • Natale A; Cordeliers Research Centre, ImMeDiab Team, INSERM, Université de Paris, Paris, France.
  • Mohanty S; Hôpital Bichat-Claude-Bernard, APHP, Department of Diabetology, Paris, France.
  • Trivedi C; Department of Cardiothoracic Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Shoemaker MB; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Yoneda ZT; Intermountain Medical Center Heart Institute, Salt Lake City, UT, USA.
  • Wells QS; Division of Cardiovascular Medicine, Department of Medicine, University of California San Diego, San Diego, CA, USA.
  • Baker MT; l'institut du thorax, INSERM, CNRS, Univ Nantes, CHU Nantes, Nantes, France.
  • Farber-Eger E; Cardiac Ultrasound Laboratory, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.
  • Michelena HI; National Heart, Lung, and Blood Institute's and Boston University's, The Framingham Heart Study, Framingham, MA, USA.
  • Lundby A; Section of Cardiovascular Medicine, Boston University School of Medicine, Boston, MA, USA.
  • Norris RA; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
  • Slaugenhaupt SA; School of Public Health, Boston University, Boston, MA, USA.
  • Dina C; National Heart, Lung, and Blood Institute's and Boston University's, The Framingham Heart Study, Framingham, MA, USA.
Eur Heart J ; 43(17): 1668-1680, 2022 05 01.
Article in En | MEDLINE | ID: mdl-35245370
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Full text: 1 Database: MEDLINE Main subject: Mitral Valve Prolapse Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limits: Adult / Humans Language: En Journal: Eur Heart J Year: 2022 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Mitral Valve Prolapse Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limits: Adult / Humans Language: En Journal: Eur Heart J Year: 2022 Type: Article Affiliation country: United States