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Destabilization of ß Cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes.
Zheng, Xiaofeng; Ho, Qing Wei Calvin; Chua, Minni; Stelmashenko, Olga; Yeo, Xin Yi; Muralidharan, Sneha; Torta, Federico; Chew, Elaine Guo Yan; Lian, Michelle Mulan; Foo, Jia Nee; Jung, Sangyong; Wong, Sunny Hei; Tan, Nguan Soon; Tong, Nanwei; Rutter, Guy A; Wenk, Markus R; Silver, David L; Berggren, Per-Olof; Ali, Yusuf.
Affiliation
  • Zheng X; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, S308232, Singapore.
  • Ho QWC; Singapore Eye Research Institute, Singapore General Hospital, S168751, Singapore.
  • Chua M; Department of Endocrinology and Metabolism, Center for Diabetes and Metabolism Research, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China.
  • Stelmashenko O; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, S308232, Singapore.
  • Yeo XY; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, S308232, Singapore.
  • Muralidharan S; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, S308232, Singapore.
  • Torta F; Singapore Eye Research Institute, Singapore General Hospital, S168751, Singapore.
  • Chew EGY; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, S138667, Singapore.
  • Lian MM; Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, S119228, Singapore.
  • Foo JN; Singapore Lipidomics Incubator, Department of Medicine, National University of Singapore, S117456, Singapore.
  • Jung S; Singapore Lipidomics Incubator, Department of Biochemistry, Life Sciences Institute and Yong Loo Lin School of Medicine, National University of Singapore, S117456, Singapore.
  • Wong SH; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, S308232, Singapore.
  • Tan NS; Human Genetics, A*STAR, Genome Institute of Singapore, S138672, Singapore.
  • Tong N; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, S308232, Singapore.
  • Rutter GA; Human Genetics, A*STAR, Genome Institute of Singapore, S138672, Singapore.
  • Wenk MR; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, S308232, Singapore.
  • Silver DL; Human Genetics, A*STAR, Genome Institute of Singapore, S138672, Singapore.
  • Berggren PO; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, S138667, Singapore.
  • Ali Y; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, S117593, Singapore.
Proc Natl Acad Sci U S A ; 119(11): e2113074119, 2022 03 15.
Article in En | MEDLINE | ID: mdl-35254894
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Full text: 1 Database: MEDLINE Main subject: Diabetes Mellitus / Insulin-Secreting Cells / Lipid Metabolism / Lipid Droplets / Membrane Proteins Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Type: Article Affiliation country: Singapore
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Full text: 1 Database: MEDLINE Main subject: Diabetes Mellitus / Insulin-Secreting Cells / Lipid Metabolism / Lipid Droplets / Membrane Proteins Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Type: Article Affiliation country: Singapore