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A SURF4-to-proteoglycan relay mechanism that mediates the sorting and secretion of a tagged variant of sonic hedgehog.
Tang, Xiao; Chen, Rong; Mesias, Vince St Dollente; Wang, Tingxuan; Wang, Ying; Poljak, Kristina; Fan, Xinyu; Miao, Hanchi; Hu, Junjie; Zhang, Liang; Huang, Jinqing; Yao, Shuhuai; Miller, Elizabeth A; Guo, Yusong.
Affiliation
  • Tang X; Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China.
  • Chen R; Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Hong Kong, China.
  • Mesias VSD; Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
  • Wang T; Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China.
  • Wang Y; Department of Biomedical Sciences, The City University of Hong Kong, Hong Kong, China.
  • Poljak K; Cell Biology Division, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
  • Fan X; Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China.
  • Miao H; National Laboratory of Biomacromolecules, Chinese Academy of Sciences Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
  • Hu J; National Laboratory of Biomacromolecules, Chinese Academy of Sciences Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
  • Zhang L; Department of Biomedical Sciences, The City University of Hong Kong, Hong Kong, China.
  • Huang J; Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
  • Yao S; Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Hong Kong, China.
  • Miller EA; Department of Mechanical and Aerospace Engineering, The Hong Kong University of Science and Technology, Hong Kong, China.
  • Guo Y; Cell Biology Division, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
Proc Natl Acad Sci U S A ; 119(11): e2113991119, 2022 03 15.
Article in En | MEDLINE | ID: mdl-35271396
ABSTRACT
SignificanceSonic Hedgehog (Shh) is a key signaling molecule that plays important roles in embryonic patterning, cell differentiation, and organ development. Although fundamentally important, the molecular mechanisms that regulate secretion of newly synthesized Shh are still unclear. Our study reveals a role for the cargo receptor, SURF4, in facilitating export of Shh from the endoplasmic reticulum (ER) via a ER export signal. In addition, our study provides evidence suggesting that proteoglycans promote the dissociation of SURF4 from Shh at the Golgi, suggesting a SURF4-to-proteoglycan relay mechanism. These analyses provide insight into an important question in cell biology how do cargo receptors capture their clients in one compartment, then disengage at their destination?
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Full text: 1 Database: MEDLINE Main subject: Proteoglycans / Hedgehog Proteins / Membrane Proteins Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Type: Article Affiliation country: China
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Full text: 1 Database: MEDLINE Main subject: Proteoglycans / Hedgehog Proteins / Membrane Proteins Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Type: Article Affiliation country: China