A SURF4-to-proteoglycan relay mechanism that mediates the sorting and secretion of a tagged variant of sonic hedgehog.
Proc Natl Acad Sci U S A
; 119(11): e2113991119, 2022 03 15.
Article
in En
| MEDLINE
| ID: mdl-35271396
ABSTRACT
SignificanceSonic Hedgehog (Shh) is a key signaling molecule that plays important roles in embryonic patterning, cell differentiation, and organ development. Although fundamentally important, the molecular mechanisms that regulate secretion of newly synthesized Shh are still unclear. Our study reveals a role for the cargo receptor, SURF4, in facilitating export of Shh from the endoplasmic reticulum (ER) via a ER export signal. In addition, our study provides evidence suggesting that proteoglycans promote the dissociation of SURF4 from Shh at the Golgi, suggesting a SURF4-to-proteoglycan relay mechanism. These analyses provide insight into an important question in cell biology how do cargo receptors capture their clients in one compartment, then disengage at their destination?
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Proteoglycans
/
Hedgehog Proteins
/
Membrane Proteins
Limits:
Humans
Language:
En
Journal:
Proc Natl Acad Sci U S A
Year:
2022
Type:
Article
Affiliation country:
China