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Hexachlorophene, a selective SHP2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS/MEK/ERK and PI3K/AKT signaling pathways.
Fu, Nai-Jie; Xi, Rui-Ying; Shi, Xiao-Ke; Li, Run-Ze; Zhang, Zhong-Hui; Li, Ling-Yu; Zhang, Guo-Lin; Wang, Fei.
Affiliation
  • Fu NJ; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China; University of Chinese Academy of Sciences, Beijing, China.
  • Xi RY; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China; University of Chinese Academy of Sciences, Beijing, China.
  • Shi XK; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China; University of Chinese Academy of Sciences, Beijing, China.
  • Li RZ; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China; University of Chinese Academy of Sciences, Beijing, China.
  • Zhang ZH; College of Chemical Engineering, Sichuan University, Chengdu 610064, China.
  • Li LY; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China; University of Chinese Academy of Sciences, Beijing, China.
  • Zhang GL; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China. Electronic address: zhanggl@cib.ac.cn.
  • Wang F; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China. Electronic address: wangfei@cib.ac.cn.
Toxicol Appl Pharmacol ; 441: 115988, 2022 04 15.
Article in En | MEDLINE | ID: mdl-35307375
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Full text: 1 Database: MEDLINE Main subject: Carcinoma, Non-Small-Cell Lung / Lung Neoplasms Limits: Humans Language: En Journal: Toxicol Appl Pharmacol Year: 2022 Type: Article Affiliation country: China
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Full text: 1 Database: MEDLINE Main subject: Carcinoma, Non-Small-Cell Lung / Lung Neoplasms Limits: Humans Language: En Journal: Toxicol Appl Pharmacol Year: 2022 Type: Article Affiliation country: China