Fission yeast Duf89 and Duf8901 are cobalt/nickel-dependent phosphatase-pyrophosphatases that act via a covalent aspartyl-phosphate intermediate.

Sanchez, Ana M; Jacewicz, Agata; Shuman, Stewart

Sanchez, Ana M; Jacewicz, Agata; Shuman, Stewart.

Affiliation

Sanchez AM; Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, New York, USA.
Jacewicz A; Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Shuman S; Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA. Electronic address: shumans@mskcc.org.

J Biol Chem ; 298(5): 101851, 2022 05.

Article in En | MEDLINE | ID: mdl-35314193

Subject(s)

Pyrophosphatases; Schizosaccharomyces pombe Proteins; Schizosaccharomyces; Cobalt/metabolism; Crystallography, X-Ray; Nickel/metabolism; Phosphates/metabolism; Protein Conformation; Pyrophosphatases/metabolism; Schizosaccharomyces/enzymology; Schizosaccharomyces/genetics; Schizosaccharomyces pombe Proteins/metabolism

Key words

Schizosaccharomyces pombe; X-ray crystallography; enzyme mechanism; phosphatase; protein structure

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Full text: 1 Database: MEDLINE Main subject: Pyrophosphatases / Schizosaccharomyces / Schizosaccharomyces pombe Proteins Language: En Journal: J Biol Chem Year: 2022 Type: Article Affiliation country: United States

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