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Aberrant motor contagion of emotions in psychopathy and high-functioning autism.
Sun, Lihua; Lukkarinen, Lasse; Noppari, Tuomo; Nazari-Farsani, Sanaz; Putkinen, Vesa; Seppälä, Kerttu; Hudson, Matthew; Tani, Pekka; Lindberg, Nina; Karlsson, Henry K; Hirvonen, Jussi; Salomaa, Marja; Venetjoki, Niina; Lauerma, Hannu; Tiihonen, Jari; Nummenmaa, Lauri.
Affiliation
  • Sun L; Turku PET Centre, University of Turku, Turku FI-20521, Finland.
  • Lukkarinen L; Turku PET Centre, Turku University Hospital, Turku FI-20521, Finland.
  • Noppari T; Department of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China.
  • Nazari-Farsani S; Turku PET Centre, University of Turku, Turku FI-20521, Finland.
  • Putkinen V; Turku PET Centre, Turku University Hospital, Turku FI-20521, Finland.
  • Seppälä K; Psychiatric Hospital for Prisoners, Health Care Services for Prisoners, Turku FI-20251, Finland.
  • Hudson M; Department of Psychiatry, Turku University Hospital, Turku FI-20251, Finland.
  • Tani P; Department of Psychiatry, Helsinki University Hospital, Helsinki FI-00014, Finland.
  • Lindberg N; Turku PET Centre, University of Turku, Turku FI-20521, Finland.
  • Karlsson HK; Turku PET Centre, University of Turku, Turku FI-20521, Finland.
  • Hirvonen J; Turku PET Centre, University of Turku, Turku FI-20521, Finland.
  • Salomaa M; Department of Medical Physics, Turku University Hospital, Turku, Finland.
  • Venetjoki N; Turku PET Centre, University of Turku, Turku FI-20521, Finland.
  • Lauerma H; Department of Psychiatry, Helsinki University Hospital, Helsinki FI-00014, Finland.
  • Tiihonen J; Department of Forensic Psychiatry, Helsinki University Hospital, University of Helsinki, Helsinki FI-00014, Finland.
  • Nummenmaa L; Turku PET Centre, University of Turku, Turku FI-20521, Finland.
Cereb Cortex ; 33(2): 374-384, 2022 12 20.
Article in En | MEDLINE | ID: mdl-35332920
Psychopathy and autism are both associated with aberrant social skills and empathy, yet only psychopaths are markedly antisocial and violent. Here, we compared the functional neural alterations underlying these two groups that both have aberrant empathetic abilities but distinct behavioral phenotypes. We studied 19 incarcerated male offenders with high psychopathic traits, 20 males with high-functioning autism, and 19 age-matched healthy controls. All groups underwent functional magnetic resonance imaging while they viewed dynamic happy, angry, and disgusted faces or listened to laughter and crying sounds. Psychopathy was associated with reduced somatomotor responses to almost all expressions, while participants with autism demonstrated less marked and emotion-specific alterations in the somatomotor area. These data suggest that psychopathy and autism involve both common and distinct functional alterations in the brain networks involved in the socioemotional processing. The alterations are more profound in psychopathy, possibly reflecting the more severely disturbed socioemotional brain networks in this population.
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Full text: 1 Database: MEDLINE Main subject: Autistic Disorder Limits: Humans / Male Language: En Journal: Cereb Cortex Journal subject: CEREBRO Year: 2022 Type: Article Affiliation country: Finland

Full text: 1 Database: MEDLINE Main subject: Autistic Disorder Limits: Humans / Male Language: En Journal: Cereb Cortex Journal subject: CEREBRO Year: 2022 Type: Article Affiliation country: Finland