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Polygenic transcriptome risk scores for COPD and lung function improve cross-ethnic portability of prediction in the NHLBI TOPMed program.
Hu, Xiaowei; Qiao, Dandi; Kim, Wonji; Moll, Matthew; Balte, Pallavi P; Lange, Leslie A; Bartz, Traci M; Kumar, Rajesh; Li, Xingnan; Yu, Bing; Cade, Brian E; Laurie, Cecelia A; Sofer, Tamar; Ruczinski, Ingo; Nickerson, Deborah A; Muzny, Donna M; Metcalf, Ginger A; Doddapaneni, Harshavardhan; Gabriel, Stacy; Gupta, Namrata; Dugan-Perez, Shannon; Cupples, L Adrienne; Loehr, Laura R; Jain, Deepti; Rotter, Jerome I; Wilson, James G; Psaty, Bruce M; Fornage, Myriam; Morrison, Alanna C; Vasan, Ramachandran S; Washko, George; Rich, Stephen S; O'Connor, George T; Bleecker, Eugene; Kaplan, Robert C; Kalhan, Ravi; Redline, Susan; Gharib, Sina A; Meyers, Deborah; Ortega, Victor; Dupuis, Josée; London, Stephanie J; Lappalainen, Tuuli; Oelsner, Elizabeth C; Silverman, Edwin K; Barr, R Graham; Thornton, Timothy A; Wheeler, Heather E; Cho, Michael H; Im, Hae Kyung.
Affiliation
  • Hu X; Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.
  • Qiao D; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Kim W; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Moll M; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Balte PP; Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY 10032, USA.
  • Lange LA; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado School of Medicine Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Bartz TM; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.
  • Kumar R; Division of Allergy and Clinical Immunology, Ann and Robert H. Lurie Children's Hospital, Chicago, IL 60611, USA; Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
  • Li X; Department of Medicine, University of Arizona, Tucson, AZ 85724, USA.
  • Yu B; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Cade BE; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Laurie CA; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
  • Sofer T; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Ruczinski I; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
  • Nickerson DA; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
  • Muzny DM; The Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
  • Metcalf GA; The Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
  • Doddapaneni H; The Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
  • Gabriel S; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Gupta N; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Dugan-Perez S; The Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
  • Cupples LA; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.
  • Loehr LR; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Jain D; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
  • Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
  • Wilson JG; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA.
  • Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Systems and Population Health, University of Washington, Seattle, WA 98101, USA.
  • Fornage M; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas
  • Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Vasan RS; Boston University and the National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA; Department of Preventive Medicine and Epidemiology, School of Medicine and Public Health, Boston University, Boston, MA 02118, USA.
  • Washko G; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.
  • O'Connor GT; Pulmonary Center, Boston University, School of Medicine, Boston, MA 02118, USA.
  • Bleecker E; Department of Medicine, University of Arizona, Tucson, AZ 85724, USA.
  • Kaplan RC; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
  • Kalhan R; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
  • Redline S; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Gharib SA; Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, WA 98109, USA.
  • Meyers D; Department of Medicine, University of Arizona, Tucson, AZ 85724, USA.
  • Ortega V; Pulmonary and Critical Care, School of Medicine, Wake Forest University, Winston-Salem, NC 27157, USA.
  • Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.
  • London SJ; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Durham, NC 27709, USA.
  • Lappalainen T; New York Genome Center, New York, NY 10013, USA; Department of Systems Biology, Columbia University, New York, NY 10032, USA.
  • Oelsner EC; Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY 10032, USA.
  • Silverman EK; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Barr RG; Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY 10032, USA.
  • Thornton TA; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
  • Wheeler HE; Department of Biology, Loyola University Chicago, Chicago, IL 60660, USA.
  • Cho MH; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Im HK; Section of Genetic Medicine, The University of Chicago, Chicago, IL 60637, USA.
Am J Hum Genet ; 109(5): 857-870, 2022 05 05.
Article in En | MEDLINE | ID: mdl-35385699
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Full text: 1 Database: MEDLINE Main subject: Pulmonary Disease, Chronic Obstructive / Transcriptome Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Country/Region as subject: America do norte Language: En Journal: Am J Hum Genet Year: 2022 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Pulmonary Disease, Chronic Obstructive / Transcriptome Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Country/Region as subject: America do norte Language: En Journal: Am J Hum Genet Year: 2022 Type: Article Affiliation country: United States