Aflatoxin levels and prevalence of TP53 aflatoxin-mutations in hepatocellular carcinomas in Mexico.
Salud Publica Mex
; 64(1): 35-40, 2022 Feb 25.
Article
in En
| MEDLINE
| ID: mdl-35438902
ABSTRACT
OBJECTIVE:
To determine the exposure to aflatoxin B1 (AFB1) in southern Mexico and the presence of the aflatoxin signature mutation in hepatocellular carcinoma (HCC) tissue from patients from a cancer referral center. MATERIALS ANDMETHODS:
We estimated the prevalence and distribution of AFB1 in a representative sample of 100 women and men from Chiapas using the National Health and Nutrition Survey 2018-19. We also examined the presence of the aflatoxin signature mutation in codon 249 (R249S), and other relevant mutations of the TP53 gene in HCC tissue blocks from 24 women and 26 men treated in a national cancer referral center.RESULTS:
The prevalence of AFB1 in serum samples was 85.5% (95%CI 72.1-93.1) and the median AFB1 was 0.117 pg/µL (IQR, 0.050-0.350). We detected TP53 R249S in three of the 50 HCCs (6.0%) and observed four other G>T transversions potentially induced by AFB1.CONCLUSION:
Our analysis provides evidence that AFB1 may have a relevant role on HCC etiology in Mexico.
Full text:
1
Database:
MEDLINE
Main subject:
Carcinoma, Hepatocellular
/
Aflatoxins
/
Liver Neoplasms
Type of study:
Prevalence_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Mexico
Language:
En
Journal:
Salud Publica Mex
Year:
2022
Type:
Article
Affiliation country:
Mexico