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Discovery by Virtual Screening of an Inhibitor of CDK5-Mediated PPARγ Phosphorylation.
O'Mahony, Gavin; Petersen, Jens; Ek, Margareta; Rae, Rebecca; Johansson, Carina; Jianming, Liu; Prokoph, Nina; Bergström, Fredrik; Bamberg, Krister; Giordanetto, Fabrizio; Zarrouki, Bader; Karlsson, Daniel; Hogner, Anders.
Affiliation
  • O'Mahony G; Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg 43183, Sweden.
  • Petersen J; Mechanistic and Structural Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg 43183, Sweden.
  • Ek M; Mechanistic and Structural Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg 43183, Sweden.
  • Rae R; Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Gothenburg 43183, Sweden.
  • Johansson C; Mechanistic and Structural Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg 43183, Sweden.
  • Jianming L; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg 43183, Sweden.
  • Prokoph N; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg 43183, Sweden.
  • Bergström F; DMPK, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg 43183, Sweden.
  • Bamberg K; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg 43183, Sweden.
  • Giordanetto F; Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg 43183, Sweden.
  • Zarrouki B; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg 43183, Sweden.
  • Karlsson D; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg 43183, Sweden.
  • Hogner A; Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg 43183, Sweden.
ACS Med Chem Lett ; 13(4): 681-686, 2022 Apr 14.
Article in En | MEDLINE | ID: mdl-35450368
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Full text: 1 Database: MEDLINE Type of study: Diagnostic_studies / Screening_studies Language: En Journal: ACS Med Chem Lett Year: 2022 Type: Article Affiliation country: Sweden
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Full text: 1 Database: MEDLINE Type of study: Diagnostic_studies / Screening_studies Language: En Journal: ACS Med Chem Lett Year: 2022 Type: Article Affiliation country: Sweden