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A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers.
Koppula, Pranavi; Lei, Guang; Zhang, Yilei; Yan, Yuelong; Mao, Chao; Kondiparthi, Lavanya; Shi, Jiejun; Liu, Xiaoguang; Horbath, Amber; Das, Molina; Li, Wei; Poyurovsky, Masha V; Olszewski, Kellen; Gan, Boyi.
Affiliation
  • Koppula P; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
  • Lei G; The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, 77030, USA.
  • Zhang Y; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
  • Yan Y; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
  • Mao C; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
  • Kondiparthi L; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
  • Shi J; Kadmon Corporation, LLC, New York, NY, 10016, USA.
  • Liu X; Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, 92697, USA.
  • Horbath A; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
  • Das M; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
  • Li W; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
  • Poyurovsky MV; Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, 92697, USA.
  • Olszewski K; Kadmon Corporation, LLC, New York, NY, 10016, USA.
  • Gan B; Kadmon Corporation, LLC, New York, NY, 10016, USA.
Nat Commun ; 13(1): 2206, 2022 04 22.
Article in En | MEDLINE | ID: mdl-35459868
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Full text: 1 Database: MEDLINE Main subject: Ubiquinone / Mitochondrial Proteins / Apoptosis Regulatory Proteins / Ferroptosis / Lung Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2022 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Ubiquinone / Mitochondrial Proteins / Apoptosis Regulatory Proteins / Ferroptosis / Lung Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2022 Type: Article Affiliation country: United States