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Cysteine metabolic engineering and selective disulfide reduction produce superior antibody-drug-conjugates.
Procopio-Melino, Renée; Kotch, Frank W; Prashad, Amar S; Gomes, Jose M; Wang, Wenge; Arve, Bo; Dawdy, Andrew; Chen, Lawrence; Sperry, Justin; Hosselet, Christine; He, Tao; Kriz, Ronald; Lin, Laura; Marquette, Kimberly; Tchistiakova, Lioudmila; Somers, Will; Rouse, Jason C; Zhong, Xiaotian.
Affiliation
  • Procopio-Melino R; BioProcess R&D, Biotherapeutics Pharmaceutical Sciences, Medicinal Sciences, Pfizer Worldwide R&D, 1 Burtt Road, Andover, MA, 01810, USA.
  • Kotch FW; BioProcess R&D, Biotherapeutics Pharmaceutical Sciences, Medicinal Sciences, Pfizer Worldwide R&D, 875 Chesterfield Parkway West, Chesterfield, MO, 63017, USA. Frank.W.Kotch@pfizer.com.
  • Prashad AS; BioProcess R&D, Biotherapeutics Pharmaceutical Sciences, Medicinal Sciences, Pfizer Worldwide R&D, 875 Chesterfield Parkway West, Chesterfield, MO, 63017, USA.
  • Gomes JM; Pearl River Laboratories Inc, 401 North Middletown Road, Pearl River, NY, 10965, USA.
  • Wang W; BioProcess R&D, Biotherapeutics Pharmaceutical Sciences, Medicinal Sciences, Pfizer Worldwide R&D, 1 Burtt Road, Andover, MA, 01810, USA. Jose.Gomes@pfizer.com.
  • Arve B; BioProcess R&D, Biotherapeutics Pharmaceutical Sciences, Medicinal Sciences, Pfizer Worldwide R&D, 1 Burtt Road, Andover, MA, 01810, USA.
  • Dawdy A; BioProcess R&D, Biotherapeutics Pharmaceutical Sciences, Medicinal Sciences, Pfizer Worldwide R&D, 875 Chesterfield Parkway West, Chesterfield, MO, 63017, USA.
  • Chen L; Analytical R&D, Biotherapeutics Pharmaceutical Sciences, Medicinal Sciences, Pfizer Worldwide R&D, 875 Chesterfield Parkway West, Chesterfield, MO, 63017, USA. Andrew.W.Dawdy@pfizer.com.
  • Sperry J; Analytical R&D, Biotherapeutics Pharmaceutical Sciences, Medicinal Sciences, Pfizer Worldwide R&D, 1 Burtt Road, Andover, MA, 01810, USA.
  • Hosselet C; Analytical R&D, Biotherapeutics Pharmaceutical Sciences, Medicinal Sciences, Pfizer Worldwide R&D, 875 Chesterfield Parkway West, Chesterfield, MO, 63017, USA.
  • He T; Vaccine Research, Pfizer Worldwide R&D, 401 North Middletown Road, Pearl River, NY, 10965, USA.
  • Kriz R; BioMedicine Design, Medicinal Sciences, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • Lin L; JOINN Biologics US Inc., 2600 Hilltop Dr., Richmond, CA, 94806, USA.
  • Marquette K; BioMedicine Design, Medicinal Sciences, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • Tchistiakova L; BioMedicine Design, Medicinal Sciences, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • Somers W; BioMedicine Design, Medicinal Sciences, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • Rouse JC; BioMedicine Design, Medicinal Sciences, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • Zhong X; BioMedicine Design, Medicinal Sciences, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
Sci Rep ; 12(1): 7262, 2022 05 04.
Article in En | MEDLINE | ID: mdl-35508689
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Full text: 1 Database: MEDLINE Main subject: Immunoconjugates / Antineoplastic Agents Limits: Animals Language: En Journal: Sci Rep Year: 2022 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Immunoconjugates / Antineoplastic Agents Limits: Animals Language: En Journal: Sci Rep Year: 2022 Type: Article Affiliation country: United States