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sp2-Iminosugars targeting human lysosomal ß-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease.
González-Cuesta, Manuel; Herrera-González, Irene; García-Moreno, M Isabel; Ashmus, Roger A; Vocadlo, David J; García Fernández, José M; Nanba, Eiji; Higaki, Katsumi; Ortiz Mellet, Carmen.
Affiliation
  • González-Cuesta M; Department of Organic Chemistry, Faculty of Chemistry, University of Seville, Sevilla, Spain.
  • Herrera-González I; Department of Organic Chemistry, Faculty of Chemistry, University of Seville, Sevilla, Spain.
  • García-Moreno MI; Department of Organic Chemistry, Faculty of Chemistry, University of Seville, Sevilla, Spain.
  • Ashmus RA; Department of Chemistry and Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, Canada.
  • Vocadlo DJ; Department of Chemistry and Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, Canada.
  • García Fernández JM; Instituto de Investigaciones Químicas (IIQ), Consejo Superior de Investigaciones Científicas (CSIC) - Universidad de Sevilla, Sevilla, Spain.
  • Nanba E; Organization for Research Initiative and Promotion, Tottori University, Yonago, Japan.
  • Higaki K; Organization for Research Initiative and Promotion, Tottori University, Yonago, Japan.
  • Ortiz Mellet C; Department of Organic Chemistry, Faculty of Chemistry, University of Seville, Sevilla, Spain.
J Enzyme Inhib Med Chem ; 37(1): 1364-1374, 2022 Dec.
Article in En | MEDLINE | ID: mdl-35575117
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Full text: 1 Database: MEDLINE Main subject: Tay-Sachs Disease Limits: Humans Language: En Journal: J Enzyme Inhib Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2022 Type: Article Affiliation country: Spain
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Tay-Sachs Disease Limits: Humans Language: En Journal: J Enzyme Inhib Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2022 Type: Article Affiliation country: Spain