ARISE: First-In-Human Evaluation of a Novel Stent Graft to Treat Ascending Aortic Dissection.
J Endovasc Ther
; 30(4): 550-560, 2023 Aug.
Article
in En
| MEDLINE
| ID: mdl-35587698
ABSTRACT
BACKGROUND:
Operative mortality for type A aortic dissection is still 10-20% at centers of excellence. Additionally, 10-20% are not considered as viable candidates for open surgical repair and not offered life-saving emergency surgery. ARISE is a multicenter investigation evaluating the novel GORE® Ascending Stent Graft (ASG; Flagstaff, AZ).OBJECTIVE:
The purpose of this study is to assess early feasibility of using these investigational devices to treat ascending aortic dissection.METHODS:
This a prospective, multicenter, non-randomized, single-arm study that enrolls patients at high surgical risk with appropriate anatomical requirements based on computed tomography imaging at 7 of 9 US sites. Devices are delivered transfemorally under fluoroscopic guidance. Primary endpoint is all-cause mortality at 30 days. Secondary endpoints include major adverse cardiovascular and cerebrovascular events (MACCE) at 30 days, 6 months, and 12 months.RESULTS:
Nineteen patients were enrolled with a mean age of 75.7 years (range 47-91) and 11 (57.9%) were female. Ten (52.6%) had DeBakey type I disease, and the rest were type II. Sixteen (84.2%) of the patients were acute. Patients were treated with safe access, (7/19 (36.8%) percutaneous, 10/19 (52.6%) transfemoral, 2/19 (10.5%) iliac conduit), delivery, and deployment completed in all cases. Median procedure time was 154 mins (range 52-392) and median contrast used was 111 mL (range 75-200). MACCE at 30 days occurred in 5 patients including mortality 3/19 (15.8%), disabling stroke in 1/19 (5.3%), and myocardial infarction in 1/19 (5.3%).CONCLUSION:
Results from the ARISE early feasibility study of a specific ascending stent graft device to treat ascending aortic dissection are promising.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Aortic Aneurysm, Thoracic
/
Blood Vessel Prosthesis Implantation
/
Endovascular Procedures
/
Dissection, Ascending Aorta
Type of study:
Clinical_trials
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Endovasc Ther
Journal subject:
ANGIOLOGIA
Year:
2023
Type:
Article
Affiliation country:
United States