Antitrypanosomal effect of allopurinol: conversion in vivo to aminopyrazolopyrimidine nucleotides by Trypanosoma curzi.
Science
; 201(4360): 1018-20, 1978 Sep 15.
Article
in En
| MEDLINE
| ID: mdl-356267
ABSTRACT
The parasite Trypanosoma cruzi metabolizes allopurinol by a sequential conversion to allopurinol mononucleotide and aminopurinol mononucleotide. The latter is incorporated into RNA. This transformation of a widely used innocuous agent, allopurinol, into a toxic adenine analog appears to account for the antiprotozoan effect of allopurinol. These unique enzymatic activities appear to occur only in T. cruzi and the pathogenic lesihaminae. Allopurinol may serve as a model for the synthesis of similar antiprotozoan agents.
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Database:
MEDLINE
Main subject:
Pyrimidine Nucleotides
/
Trypanocidal Agents
/
Trypanosoma cruzi
/
Allopurinol
Limits:
Animals
Language:
En
Journal:
Science
Year:
1978
Type:
Article