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At Critically Low Antigen Densities, IgM Hexamers Outcompete Both IgM Pentamers and IgG1 for Human Complement Deposition and Complement-Dependent Cytotoxicity.
Oskam, Nienke; Ooijevaar-de Heer, Pleuni; Derksen, Ninotska I L; Kruithof, Simone; de Taeye, Steven W; Vidarsson, Gestur; Reijm, Sanne; Kissel, Theresa; Toes, René E M; Rispens, Theo.
Affiliation
  • Oskam N; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, the Netherlands; n.oskam@sanquin.nl.
  • Ooijevaar-de Heer P; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, the Netherlands.
  • Derksen NIL; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, the Netherlands.
  • Kruithof S; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, the Netherlands.
  • de Taeye SW; Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, the Netherlands; and.
  • Vidarsson G; Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, the Netherlands; and.
  • Reijm S; Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands.
  • Kissel T; Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands.
  • Toes REM; Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands.
  • Rispens T; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, the Netherlands.
J Immunol ; 209(1): 16-25, 2022 07 01.
Article in En | MEDLINE | ID: mdl-35705253
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Full text: 1 Database: MEDLINE Main subject: Immunoglobulin G / Immunoglobulin J-Chains Limits: Humans Language: En Journal: J Immunol Year: 2022 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Immunoglobulin G / Immunoglobulin J-Chains Limits: Humans Language: En Journal: J Immunol Year: 2022 Type: Article