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ADAR1 downregulation by autophagy drives senescence independently of RNA editing by enhancing p16INK4a levels.
Hao, Xue; Shiromoto, Yusuke; Sakurai, Masayuki; Towers, Martina; Zhang, Qiang; Wu, Shuai; Havas, Aaron; Wang, Lu; Berger, Shelley; Adams, Peter D; Tian, Bin; Nishikura, Kazuko; Kossenkov, Andrew V; Liu, Pingyu; Zhang, Rugang.
Affiliation
  • Hao X; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA.
  • Shiromoto Y; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.
  • Sakurai M; Department of Molecular Genetics, Graduate School of Medicine Kyoto University, Kyoto, Japan.
  • Towers M; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.
  • Zhang Q; Research Institute for Biomedical Sciences, Tokyo University of Science, Chiba, Japan.
  • Wu S; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA.
  • Havas A; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.
  • Wang L; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.
  • Berger S; Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA, USA.
  • Adams PD; Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Tian B; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Nishikura K; Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Kossenkov AV; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Liu P; Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA, USA.
  • Zhang R; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.
Nat Cell Biol ; 24(8): 1202-1210, 2022 08.
Article in En | MEDLINE | ID: mdl-35851616
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Full text: 1 Database: MEDLINE Main subject: Adenosine Deaminase / Cyclin-Dependent Kinase Inhibitor p16 Limits: Animals / Female / Humans Language: En Journal: Nat Cell Biol Year: 2022 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Adenosine Deaminase / Cyclin-Dependent Kinase Inhibitor p16 Limits: Animals / Female / Humans Language: En Journal: Nat Cell Biol Year: 2022 Type: Article Affiliation country: United States