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RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition.
Nunes, Carolina; Depestel, Lisa; Mus, Liselot; Keller, Kaylee M; Delhaye, Louis; Louwagie, Amber; Rishfi, Muhammad; Whale, Alex; Kara, Neesha; Andrews, Simon R; Dela Cruz, Filemon; You, Daoqi; Siddiquee, Armaan; Cologna, Camila Takeno; De Craemer, Sam; Dolman, Emmy; Bartenhagen, Christoph; De Vloed, Fanny; Sanders, Ellen; Eggermont, Aline; Bekaert, Sarah-Lee; Van Loocke, Wouter; Bek, Jan Willem; Dewyn, Givani; Loontiens, Siebe; Van Isterdael, Gert; Decaesteker, Bieke; Tilleman, Laurentijn; Van Nieuwerburgh, Filip; Vermeirssen, Vanessa; Van Neste, Christophe; Ghesquiere, Bart; Goossens, Steven; Eyckerman, Sven; De Preter, Katleen; Fischer, Matthias; Houseley, Jon; Molenaar, Jan; De Wilde, Bram; Roberts, Stephen S; Durinck, Kaat; Speleman, Frank.
Affiliation
  • Nunes C; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
  • Depestel L; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
  • Mus L; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
  • Keller KM; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
  • Delhaye L; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
  • Louwagie A; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
  • Rishfi M; Princess Maxima Center, Utrecht, Netherlands.
  • Whale A; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
  • Kara N; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
  • Andrews SR; VIB-UGent Center for Medical Biotechnology, Ghent University, Ghent, Belgium.
  • Dela Cruz F; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
  • You D; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
  • Siddiquee A; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
  • Cologna CT; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
  • De Craemer S; Epigenetics Programme, Babraham Institute, Cambridge, UK.
  • Dolman E; Epigenetics Programme, Babraham Institute, Cambridge, UK.
  • Bartenhagen C; Epigenetics Programme, Babraham Institute, Cambridge, UK.
  • De Vloed F; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Sanders E; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Eggermont A; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Bekaert SL; Metabolomics Expertise Center, Center for Cancer Biology (CCB), VIB, Leuven, Belgium.
  • Van Loocke W; Metabolomics Expertise Center, Department of Oncology, KU Leuven, Leuven, Belgium.
  • Bek JW; Metabolomics Expertise Center, Center for Cancer Biology (CCB), VIB, Leuven, Belgium.
  • Dewyn G; Metabolomics Expertise Center, Department of Oncology, KU Leuven, Leuven, Belgium.
  • Loontiens S; Princess Maxima Center, Utrecht, Netherlands.
  • Van Isterdael G; Center for Molecular Medicine Cologne, Cologne (CMMC), Medical Faculty, University of Cologne, Cologne, Germany.
  • Decaesteker B; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Cologne, Germany.
  • Tilleman L; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
  • Van Nieuwerburgh F; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
  • Vermeirssen V; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
  • Van Neste C; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
  • Ghesquiere B; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
  • Goossens S; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
  • Eyckerman S; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
  • De Preter K; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
  • Fischer M; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
  • Houseley J; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
  • Molenaar J; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
  • De Wilde B; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
  • Roberts SS; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
  • Durinck K; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
  • Speleman F; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
Sci Adv ; 8(28): eabn1382, 2022 Jul 15.
Article in En | MEDLINE | ID: mdl-35857500
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Full text: 1 Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Sci Adv Year: 2022 Type: Article Affiliation country: Belgium
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Full text: 1 Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Sci Adv Year: 2022 Type: Article Affiliation country: Belgium