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Correlation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes.
Mikolajek, Halina; Weckener, Miriam; Brotzakis, Z Faidon; Huo, Jiandong; Dalietou, Evmorfia V; Le Bas, Audrey; Sormanni, Pietro; Harrison, Peter J; Ward, Philip N; Truong, Steven; Moynie, Lucile; Clare, Daniel K; Dumoux, Maud; Dormon, Joshua; Norman, Chelsea; Hussain, Naveed; Vogirala, Vinod; Owens, Raymond J; Vendruscolo, Michele; Naismith, James H.
Affiliation
  • Mikolajek H; Electron Bio-Imaging Centre, Diamond Light Source, Didcot OX11 0DE, United Kingdom.
  • Weckener M; Protein Production UK, The Research Complex at Harwell, Didcot OX11 OFA, United Kingdom.
  • Brotzakis ZF; Structural Biology, The Rosalind Franklin Institute, Didcot OX11 OQS, United Kingdom.
  • Huo J; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom.
  • Dalietou EV; Protein Production UK, The Research Complex at Harwell, Didcot OX11 OFA, United Kingdom.
  • Le Bas A; Structural Biology, The Rosalind Franklin Institute, Didcot OX11 OQS, United Kingdom.
  • Sormanni P; Division of Structural Biology, University of Oxford, Oxford OX3 7BN, United Kingdom.
  • Harrison PJ; Structural Biology, The Rosalind Franklin Institute, Didcot OX11 OQS, United Kingdom.
  • Ward PN; Protein Production UK, The Research Complex at Harwell, Didcot OX11 OFA, United Kingdom.
  • Truong S; Structural Biology, The Rosalind Franklin Institute, Didcot OX11 OQS, United Kingdom.
  • Moynie L; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom.
  • Clare DK; Electron Bio-Imaging Centre, Diamond Light Source, Didcot OX11 0DE, United Kingdom.
  • Dumoux M; Protein Production UK, The Research Complex at Harwell, Didcot OX11 OFA, United Kingdom.
  • Dormon J; Protein Production UK, The Research Complex at Harwell, Didcot OX11 OFA, United Kingdom.
  • Norman C; Structural Biology, The Rosalind Franklin Institute, Didcot OX11 OQS, United Kingdom.
  • Hussain N; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom.
  • Vogirala V; Protein Production UK, The Research Complex at Harwell, Didcot OX11 OFA, United Kingdom.
  • Owens RJ; Structural Biology, The Rosalind Franklin Institute, Didcot OX11 OQS, United Kingdom.
  • Vendruscolo M; Electron Bio-Imaging Centre, Diamond Light Source, Didcot OX11 0DE, United Kingdom.
  • Naismith JH; Protein Production UK, The Research Complex at Harwell, Didcot OX11 OFA, United Kingdom.
Proc Natl Acad Sci U S A ; 119(31): e2205412119, 2022 08 02.
Article in En | MEDLINE | ID: mdl-35858383

Full text: 1 Database: MEDLINE Main subject: Antibodies, Neutralizing / Single-Domain Antibodies / Spike Glycoprotein, Coronavirus / SARS-CoV-2 / Antibodies, Viral / Antibody Affinity Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Type: Article Affiliation country: United kingdom

Full text: 1 Database: MEDLINE Main subject: Antibodies, Neutralizing / Single-Domain Antibodies / Spike Glycoprotein, Coronavirus / SARS-CoV-2 / Antibodies, Viral / Antibody Affinity Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Type: Article Affiliation country: United kingdom