WWOX inhibition by Zfra1-31 restores mitochondrial homeostasis and viability of neuronal cells exposed to high glucose.

Carvalho, Cristina; Correia, Sónia C; Seiça, Raquel; Moreira, Paula I

Carvalho, Cristina; Correia, Sónia C; Seiça, Raquel; Moreira, Paula I.

Affiliation

Carvalho C; Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504, Coimbra, Portugal. cristina.im.carvalho@gmail.com.
Correia SC; Center for Innovation in Biomedicine and Biotechnology (CIBB), Coimbra, Portugal. cristina.im.carvalho@gmail.com.
Seiça R; Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal. cristina.im.carvalho@gmail.com.
Moreira PI; Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504, Coimbra, Portugal.

Cell Mol Life Sci ; 79(9): 487, 2022 Aug 19.

Article in En | MEDLINE | ID: mdl-35984507

Subject(s)

Amyloid beta-Peptides; Mitochondria; Neuroblastoma; WW Domain-Containing Oxidoreductase; Animals; Humans; Rats; Amyloid beta-Peptides/metabolism; Glucose/metabolism; Glucose/pharmacology; Homeostasis; Mitochondria/metabolism; Neuroblastoma/metabolism; Oxidative Stress; Reactive Oxygen Species/metabolism; Tumor Suppressor Proteins/genetics; Tumor Suppressor Proteins/metabolism; WW Domain-Containing Oxidoreductase/genetics; WW Domain-Containing Oxidoreductase/metabolism

Key words

Diabetes; Mitochondria; Neurodegeneration; Neuroprotection; WWOX; Zfra1-31

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Full text: 1 Database: MEDLINE Main subject: Amyloid beta-Peptides / WW Domain-Containing Oxidoreductase / Mitochondria / Neuroblastoma Limits: Animals / Humans Language: En Journal: Cell Mol Life Sci Journal subject: BIOLOGIA MOLECULAR Year: 2022 Type: Article Affiliation country: Portugal

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