Distinct Molecular Mechanisms Characterizing Pathogenesis of SARS-CoV-2.
J Microbiol Biotechnol
; 32(9): 1073-1085, 2022 Sep 28.
Article
in En
| MEDLINE
| ID: mdl-36039385
ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has continued for over 2 years, following the outbreak of coronavirus-19 (COVID-19) in 2019. It has resulted in enormous casualties and severe economic crises. The rapid development of vaccines and therapeutics against SARS-CoV-2 has helped slow the spread. In the meantime, various mutations in the SARS-CoV-2 have emerged to evade current vaccines and therapeutics. A better understanding of SARS-CoV-2 pathogenesis is a prerequisite for developing efficient, advanced vaccines and therapeutics. Since the outbreak of COVID-19, a tremendous amount of research has been conducted to unveil SARSCoV-2 pathogenesis, from clinical observations to biochemical analysis at the molecular level upon viral infection. In this review, we discuss the molecular mechanisms of SARS-CoV-2 propagation and pathogenesis, with an update on recent advances.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Vaccines
/
COVID-19
Type of study:
Etiology_studies
Limits:
Humans
Language:
En
Journal:
J Microbiol Biotechnol
Year:
2022
Type:
Article