Genome-wide DNA methylation profiling of stomach cancer in the ethnic population of Mizoram, North East India.
Genomics
; 114(5): 110478, 2022 09.
Article
in En
| MEDLINE
| ID: mdl-36064073
ABSTRACT
Stomach cancer is the fifth most common cancer in terms of prevalence and incidence and the fourth leading cause of mortality in men and women worldwide. It is well-established that aberrant DNA methylation in cells can lead to carcinogenesis. The primary objective of our study was to investigate the aberrant DNA methylation status of genes associated with stomach cancer with a particular reference to the ethnic population of Mizoram, North East India. The site-level analysis identified 2883 CpG sites differentially methylated, representing â¼922 genes. Out of which 476 Differentially Methylated Positions (DMPs) were promoter-associated, 452 DMPs were hypermethylated, and 24 were hypomethylated. The region-level analysis identified 462 Differentially Methylated Regions (DMRs) corresponding to â¼320 genes, of which â¼281 genes were hypermethylated and â¼40 genes were hypomethylated. TCGA analysis showed that some of the genes had been previously implicated in other cancers including stomach cancer. Five hypermethylated genes were selected as candidate genes for further investigations and they have shown to be novel and could serve as candidate hypermethylation biomarkers for stomach cancer in this particular ethnic group.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Stomach Neoplasms
/
DNA Methylation
Type of study:
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
En
Journal:
Genomics
Journal subject:
GENETICA
Year:
2022
Type:
Article
Affiliation country:
India