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CYP2C8*3 and *4 define CYP2C8 phenotype: An approach with the substrate cinitapride.
Campodónico, Diana María; Zubiaur, Pablo; Soria-Chacartegui, Paula; Casajús, Ana; Villapalos-García, Gonzalo; Navares-Gómez, Marcos; Gómez-Fernández, Antía; Parra-Garcés, Raúl; Mejía-Abril, Gina; Román, Manuel; Martín-Vílchez, Samuel; Ochoa, Dolores; Abad-Santos, Francisco.
Affiliation
  • Campodónico DM; Clinical Pharmacology Department, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria La Princesa (IP), Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Madrid, Spain.
  • Zubiaur P; Clinical Pharmacology Department, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria La Princesa (IP), Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Madrid, Spain.
  • Soria-Chacartegui P; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.
  • Casajús A; Clinical Pharmacology Department, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria La Princesa (IP), Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Madrid, Spain.
  • Villapalos-García G; Clinical Pharmacology Department, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria La Princesa (IP), Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Madrid, Spain.
  • Navares-Gómez M; Clinical Pharmacology Department, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria La Princesa (IP), Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Madrid, Spain.
  • Gómez-Fernández A; Clinical Pharmacology Department, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria La Princesa (IP), Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Madrid, Spain.
  • Parra-Garcés R; Clinical Pharmacology Department, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria La Princesa (IP), Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Madrid, Spain.
  • Mejía-Abril G; Clinical Pharmacology Department, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria La Princesa (IP), Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Madrid, Spain.
  • Román M; Clinical Pharmacology Department, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria La Princesa (IP), Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Madrid, Spain.
  • Martín-Vílchez S; Clinical Pharmacology Department, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria La Princesa (IP), Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Madrid, Spain.
  • Ochoa D; Clinical Pharmacology Department, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria La Princesa (IP), Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Madrid, Spain.
  • Abad-Santos F; Clinical Pharmacology Department, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria La Princesa (IP), Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Clin Transl Sci ; 15(11): 2613-2624, 2022 11.
Article in En | MEDLINE | ID: mdl-36065758
Cinitapride is a gastrointestinal prokinetic drug, prescribed for the treatment of functional dyspepsia, and as an adjuvant therapy for gastroesophageal reflux disease. In this study, we aimed to explore the impact of relevant variants in CYP3A4 and CYP2C8 and other pharmacogenes, along with demographic characteristics, on cinitapride pharmacokinetics and safety; and to evaluate the impact of CYP2C8 alleles on the enzyme's function. Twenty-five healthy volunteers participating in a bioequivalence clinical trial consented to participate in the study. Participants were genotyped for 56 variants in 19 genes, including cytochrome P450 (CYP) enzymes (e.g., CYP2C8 or CYP3A4) or transporters (e.g., SLC or ABC), among others. CYP2C8*3 carriers showed a reduction in AUC of 42% and Cmax of 35% compared to *1/*1 subjects (p = 0.003 and p = 0.011, respectively). *4 allele carriers showed a 45% increase in AUC and 63% in Cmax compared to *1/*1 subjects, although these differences did not reach statistical significance. CYP2C8*3 and *4 alleles may be used to infer the following pharmacogenetic phenotypes: ultrarapid (UM) (*3/*3), rapid (RM) (*1/*3), normal (NM) (*1/*1), intermediate (IM) (*1/*4), and poor (PM) metabolizers (*4/*4). In this study, we properly characterized RMs, NMs, and IMs; however, additional studies are required to properly characterize UMs and PMs. These findings should be relevant with respect to cinitapride, but also to numerous CYP2C8 substrates such as imatinib, loperamide, montelukast, ibuprofen, paclitaxel, pioglitazone, repaglinide, or rosiglitazone.
Subject(s)

Full text: 1 Database: MEDLINE Main subject: Benzamides / Cytochrome P-450 CYP3A Language: En Journal: Clin Transl Sci Year: 2022 Type: Article Affiliation country: Spain

Full text: 1 Database: MEDLINE Main subject: Benzamides / Cytochrome P-450 CYP3A Language: En Journal: Clin Transl Sci Year: 2022 Type: Article Affiliation country: Spain