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METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma.
Zeng, Xiangyu; Zhao, Fei; Cui, Gaofeng; Zhang, Yong; Deshpande, Rajashree A; Chen, Yuping; Deng, Min; Kloeber, Jake A; Shi, Yu; Zhou, Qin; Zhang, Chao; Hou, Jing; Kim, Wootae; Tu, Xinyi; Yan, Yuanliang; Xu, Zhijie; Chen, Lifeng; Gao, Huanyao; Guo, Guijie; Liu, Jiaqi; Zhu, Qian; Cao, Yueyu; Huang, Jinzhou; Wu, Zheming; Zhu, Shouhai; Yin, Ping; Luo, Kuntian; Mer, Georges; Paull, Tanya T; Yuan, Jian; Tao, Kaixiong; Lou, Zhenkun.
Affiliation
  • Zeng X; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Zhao F; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
  • Cui G; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
  • Zhang Y; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
  • Deshpande RA; Department of Radiation Oncology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Chen Y; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.
  • Deng M; Key Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine, Shanghai, China.
  • Kloeber JA; Department of Biochemistry and Molecular Biology, Tongji University School of Medicine, Shanghai, China.
  • Shi Y; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
  • Zhou Q; State Key Laboratory of Molecular Oncology and Department of Radiation Oncology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
  • Zhang C; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
  • Hou J; Mayo Clinic Medical Scientist Training Program, Mayo Clinic, Rochester, MN, USA.
  • Kim W; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
  • Tu X; Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Yan Y; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
  • Xu Z; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
  • Chen L; Beijing Institute of Basic Medical Sciences, Beijing, China.
  • Gao H; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
  • Guo G; Department of Breast Surgery, Guizhou Provincial People's Hospital, Guiyang, China.
  • Liu J; Soonchunhyang Institute of Med-bio Science (SIMS), Soonchunhyang University, Cheonan-si, Republic of Korea.
  • Zhu Q; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
  • Cao Y; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
  • Huang J; Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.
  • Wu Z; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
  • Zhu S; Department of Pathology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
  • Yin P; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
  • Luo K; Center for Reproductive Medicine, Department of Gynecology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, China.
  • Mer G; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
  • Paull TT; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
  • Yuan J; Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou, China.
  • Tao K; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
  • Lou Z; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Nat Cancer ; 3(9): 1088-1104, 2022 09.
Article in En | MEDLINE | ID: mdl-36138131
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Full text: 1 Database: MEDLINE Main subject: Pancreatic Neoplasms / Carcinoma, Pancreatic Ductal / MRE11 Homologue Protein / Methyltransferases Limits: Humans Language: En Journal: Nat Cancer Year: 2022 Type: Article Affiliation country: China
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Full text: 1 Database: MEDLINE Main subject: Pancreatic Neoplasms / Carcinoma, Pancreatic Ductal / MRE11 Homologue Protein / Methyltransferases Limits: Humans Language: En Journal: Nat Cancer Year: 2022 Type: Article Affiliation country: China